Disinfection byproducts of haloacetaldehydes disrupt hepatic lipid metabolism and induce lipotoxicity in high-fat culture conditions
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2025-07-02
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Authors
Yang, LiliJiang, Zhiqiang
Zheng, Weiwei
Chen, Yu
Qu, Fei
Crabbe, M. James C.
Zhang, Yubin
Andersen, Melvin E.
Zheng, Yuxin
Qu, Weidong
Affiliation
Oxford UniversityFudan University
University of Bedfordshire
ScitoVation LLC.
Qingdao University
Issue Date
2024-07-02Subjects
dietary fatty acidsdrinking-water
water contamination
water quality
Subject Categories::H122 Water Quality Control
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Show full item recordAbstract
Unhealthy lifestyles, obesity, and environmental pollutants are strongly correlated with the development of nonalcoholic fatty liver disease (NAFLD). Haloacetaldehyde-associated disinfection byproducts (HAL-DBPs) at various multiples of concentrations found in finished drinking water together with high-fat (HF) were examined to gauge their mixed effects on hepatic lipid metabolism. Using new alternative methods (NAMs), studying effects in human cells in vitro for risk assessment, we investigated the combined effects of HF and HAL-DBPs on hepatic lipid metabolism and lipotoxicity in immortalized LO-2 human hepatocytes. Coexposure of HAL-DBPs at various multiples of environmental exposure levels with HF increased the levels of triglycerides, interfered with de novo lipogenesis, enhanced fatty acid oxidation, and inhibited the secretion of very low-density lipoproteins. Lipid accumulation caused by the coexposure of HAL-DBPs and HF also resulted in more severe lipotoxicity in these cells. Our results using an in vitro NAM-based method provide novel insights into metabolic reprogramming in hepatocytes due to coexposure of HF and HAL-DBPs and strongly suggest that the risk of NAFLD in sensitive populations due to HAL-DBPs and poor lifestyle deserves further investigation both with laboratory and epidemiological tools. We also discuss how results from our studies could be used in health risk assessments for HAL-DBPs.Citation
Yang L, Jiang Z, Yang L, Zheng W, Chen Y, Qu F, Crabbe MJC, Zhang Y, Andersen M, Zheng Y, Qu W (2024) 'Disinfection byproducts of haloacetaldehydes disrupt hepatic lipid metabolism and induce lipotoxicity in high-fat culture conditions', Environmental Science & Technology, 58 (28), pp.-12356–12367.Publisher
ACSAdditional Links
https://pubs.acs.org/doi/10.1021/acs.est.3c11009Type
ArticleLanguage
enISSN
0013-936XEISSN
1520-5851Sponsors
This project was supported by the National Natural Science Foundation of China (81630088 & 81325017) and the Changjiang Scholars Program, Ministry of Education (T2014089).ae974a485f413a2113503eed53cd6c53
10.1021/acs.est.3c11009
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