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dc.contributor.authorCugusi, Simona
dc.contributor.authorBajpe, Prashanth Kumar
dc.contributor.authorMitter, Richard
dc.contributor.authorPatel, Harshil
dc.contributor.authorStewart, Aengus
dc.contributor.authorSvejstrup, Jesper Q.
dc.contributor.illustrator
dc.date.accessioned2024-05-02T09:32:57Z
dc.date.available2024-05-02T09:32:57Z
dc.date.issued2022-10-22
dc.identifier.citationCugusi S, Bajpe PK, Mitter R, Patel H, Stewart A, Svejstrup JQ (2022) 'An important role for RPRD1B in the heat shock response', Molecular and Cellular Biology, 42 (10), e00173-22en_US
dc.identifier.issn0270-7306
dc.identifier.pmid36121223
dc.identifier.doi10.1128/mcb.00173-22
dc.identifier.urihttp://hdl.handle.net/10547/626252
dc.description.abstractDuring the heat shock response (HSR), heat shock factor (HSF1 in mammals) binds to target gene promoters, resulting in increased expression of heat shock proteins that help maintain protein homeostasis and ensure cell survival. Besides HSF1, only a relatively few transcription factors with a specific role in ensuring correctly regulated gene expression during the HSR have been described. Here, we use proteomic and genomic (CRISPR) screening to identify a role for RPRD1B in the response to heat shock. Indeed, cells depleted for RPRD1B are heat shock sensitive and show decreased expression of key heat shock proteins (HSPs). These results add to our understanding of the connection between basic gene expression mechanisms and the HSR.en_US
dc.description.sponsorshipThis work was supported by the Francis Crick Institute (FCI receives funding from Cancer Research UK [FC001166], the UK Medical Research Council [FC001166], and the Welcome Trust [FC001166]), and by grants to J.Q.S. from the European Research Council (Agreement 693327), a Laureate grant from the Novo Nordisk Foundation (NNF19OC0055875), and a chair grant from the Danish National Research Foundation (DNRF153).en_US
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.urlhttps://www.tandfonline.com/doi/full/10.1128/mcb.00173-22en_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9583720/en_US
dc.rightsYellow - can archive pre-print (ie pre-refereeing)
dc.subjectHSFen_US
dc.subjectHSF1en_US
dc.subjectRNA polymerase IIen_US
dc.subjectRPRD1Ben_US
dc.subjectheat shocken_US
dc.subjecttranscriptionen_US
dc.subjectSubject Categories::C760 Biomolecular Scienceen_US
dc.titleAn important role for RPRD1B in the heat shock responseen_US
dc.typeArticleen_US
dc.contributor.departmentFrancis Crick Instituteen_US
dc.contributor.departmentUniversity of Copenhagenen_US
dc.identifier.journalMolecular and Cellular Biologyen_US
dc.identifier.pmcidPMC9583720
dc.date.updated2024-05-02T09:28:07Z
dc.description.noteis freely available at pubmedcentral but NOT on T&F website - nothing at PMC to say that that copy can be shared RVO 2/5/24


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