Finger-prick autologous blood (FAB) eye drops for dry eye disease: single masked multi-dentre randomised controlled trial
Cook, Erica Jane
Bourne, Rupert Richard Alexander
AffiliationMoorfields Eye Hospital
UCL Institute of Ophthalmology
University of Bedfordshire
Comprehensive Clinical Trials Unit
Anglia Ruskin University
MetadataShow full item record
AbstractPurpose: To investigate the quantitative and qualitative efficacy of finger-prick autologous blood (FAB) eye drops versus conventional medical therapy for the treatment of severe dry eye disease (DED). Methods: Two centre, single masked, randomised controlled trial. Sixty patients in total were recruited with thirty patients (sixty eyes) treated with FAB eye drops four times per day in addition to their conventional DED treatment, and thirty patients (fifty-eight eyes) served as control subjects on conventional treatment alone. Ocular surface disease index (OSDI), Schirmer’s test, fluorescein ocular staining grade (OCSG) Oxford schema and fluorescein tear film break-up time (TBUT), were performed at baseline, at 4 and 8 weeks. Results: OSDI scores significantly decreased in the FAB arm by greater than −17.68 (−37.67 to −2.96, p=0.02) compared to the control arm. There were greater improvements in OCSG and TBUT in the FAB arm but these were non-significant (p>0.05). Conclusion: This feasibility study demonstrates adding FAB eye drops to conventional medical therapy for DED improves mean OSDI symptom score compared to conventional medical therapy alone. It may have particular use in settings where serum is unobtainable. An adequately powered and well-designed randomised trial is needed to further evaluate the long-term clinical benefit of FAB.
CitationHassan A, Balal S., Cook E, Dehbi H-B, Pardhan S, Bourne R, Ahmad S, Sharma A (2022) 'Finger-prick autologous blood (FAB) eye drops for dry eye disease: single masked multi-dentre randomised controlled trial', Clinical Ophthalmology, 16 pp. 3973-3979 .
PublisherDove Medical Press
PubMed Central IDPMC9724572
SponsorsNational Institute for Health Research (NIHR) Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-0416-20040)
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- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
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