Finger-prick autologous blood (FAB) eye drops for dry eye disease: single masked multi-dentre randomised controlled trial
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OPTH-384586-finger-prick-autol ...
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Authors
Hassan, AliBalal, Shafi
Cook, Erica Jane
Dehbi, Hakim-Moulay
Pardhan, Shahina
Bourne, Rupert Richard Alexander
Ahmad, Sajjad
Sharma, Anant
Affiliation
Moorfields Eye HospitalUCL Institute of Ophthalmology
University of Bedfordshire
Comprehensive Clinical Trials Unit
Anglia Ruskin University
Addenbrookes Hospital
Issue Date
2022-12-02
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Purpose: To investigate the quantitative and qualitative efficacy of finger-prick autologous blood (FAB) eye drops versus conventional medical therapy for the treatment of severe dry eye disease (DED). Methods: Two centre, single masked, randomised controlled trial. Sixty patients in total were recruited with thirty patients (sixty eyes) treated with FAB eye drops four times per day in addition to their conventional DED treatment, and thirty patients (fifty-eight eyes) served as control subjects on conventional treatment alone. Ocular surface disease index (OSDI), Schirmer’s test, fluorescein ocular staining grade (OCSG) Oxford schema and fluorescein tear film break-up time (TBUT), were performed at baseline, at 4 and 8 weeks. Results: OSDI scores significantly decreased in the FAB arm by greater than −17.68 (−37.67 to −2.96, p=0.02) compared to the control arm. There were greater improvements in OCSG and TBUT in the FAB arm but these were non-significant (p>0.05). Conclusion: This feasibility study demonstrates adding FAB eye drops to conventional medical therapy for DED improves mean OSDI symptom score compared to conventional medical therapy alone. It may have particular use in settings where serum is unobtainable. An adequately powered and well-designed randomised trial is needed to further evaluate the long-term clinical benefit of FAB.Citation
Hassan A, Balal S., Cook E, Dehbi H-B, Pardhan S, Bourne R, Ahmad S, Sharma A (2022) 'Finger-prick autologous blood (FAB) eye drops for dry eye disease: single masked multi-dentre randomised controlled trial', Clinical Ophthalmology, 16 pp. 3973-3979 .Publisher
Dove Medical PressJournal
Clinical OphthalmologyPubMed ID
36483187PubMed Central ID
PMC9724572Additional Links
https://www.dovepress.com/finger-prick-autologous-blood-fab-eye-drops-for-dry-eye-disease-single-peer-reviewed-fulltext-article-OPTHhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9724572/
Type
ArticleLanguage
enISSN
1177-5467Sponsors
National Institute for Health Research (NIHR) Research for Patient Benefit (RfPB) Programme (Grant Reference Number PB-PG-0416-20040)ae974a485f413a2113503eed53cd6c53
10.2147/OPTH.S384586
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