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dc.contributor.authorYánez, Diana C.
dc.contributor.authorLau, Ching-In
dc.contributor.authorPapaioannou, Eleftheria
dc.contributor.authorChawda, Mira Manilal
dc.contributor.authorRowell, Jasmine
dc.contributor.authorRoss, Susan
dc.contributor.authorFurmanski, Anna L.
dc.contributor.authorCrompton, Tessa
dc.contributor.illustrator
dc.date.accessioned2022-08-30T08:44:30Z
dc.date.available2022-08-08T00:00:00Z
dc.date.available2022-08-30T08:44:30Z
dc.date.issued2022-08-08
dc.identifier.citationYánez DC, Lau CI, Papaioannou E, Chawda MM, Rowell J, Ross S, Furmanski A, Crompton T (2022) 'The pioneer transcription factor Foxa2 modulates T helper differentiation to reduce mouse allergic airway disease', Frontiers in Immunology, 13 (890781)en_US
dc.identifier.issn1664-3224
dc.identifier.pmid36003391
dc.identifier.doi10.3389/fimmu.2022.890781
dc.identifier.urihttp://hdl.handle.net/10547/625516
dc.description.abstractFoxa2, a member of the Forkhead box (Fox) family of transcription factors, plays an important role in the regulation of lung function and lung tissue homeostasis. FOXA2 expression is reduced in the lung and airways epithelium of asthmatic patients and in mice absence of Foxa2 from the lung epithelium contributes to airway inflammation and goblet cell hyperplasia. Here we demonstrate a novel role for Foxa2 in the regulation of T helper differentiation and investigate its impact on lung inflammation. Conditional deletion of Foxa2 from T-cells led to increased Th2 cytokine secretion and differentiation, but decreased Th1 differentiation and IFN-γ expression in vitro. Induction of mouse allergic airway inflammation resulted in more severe disease in the conditional Foxa2 knockout than in control mice, with increased cellular infiltration to the lung, characterized by the recruitment of eosinophils and basophils, increased mucus production and increased production of Th2 cytokines and serum IgE. Thus, these experiments suggest that Foxa2 expression in T-cells is required to protect against the Th2 inflammatory response in allergic airway inflammation and that Foxa2 is important in T-cells to maintain the balance of effector cell differentiation and function in the lung.en_US
dc.description.sponsorshipThis work was supported by grants from the MRC, BBSRC and GOSHCCen_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relation.urlhttps://www.frontiersin.org/articles/10.3389/fimmu.2022.890781/fullen_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393229/en_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectFoxa2en_US
dc.subjectShhen_US
dc.subjectTh2 airway inflammationen_US
dc.subjectTh1en_US
dc.subjectTh2en_US
dc.subjectSubject Categories::C550 Immunologyen_US
dc.titleThe pioneer transcription factor Foxa2 modulates T helper differentiation to reduce mouse allergic airway diseaseen_US
dc.typeArticleen_US
dc.identifier.eissn1664-3224
dc.contributor.departmentUCL Great Ormond Street Institute of Child Healthen_US
dc.contributor.departmentUniversidad San Francisco de Quitoen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journalFrontiers in Immunologyen_US
dc.identifier.pmcidPMC9393229
dc.date.updated2022-08-30T08:38:21Z
dc.description.notegold open access


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