An insight into the impact of thermal process on dissolution profile and physical characteristics of theophylline tablets made through 3D printing compared to conventional methods
Authors
Nashed, NourLam, Matthew
Ghafourian, Taravat
Pausas, Lluis
Jiri, Memory
Majumder, Mridul
Nokhodchi, Ali
Issue Date
2022-06-06Subjects
3D printinghot-melt extrusion
manufacturing method
fused deposition modeling
drug release
porosity
density
Subject Categories::H812 Pharmaceutical Engineering
Metadata
Show full item recordAbstract
The dissolution profile is of great importance in drug delivery and is affected by the manufacturing method. Thus, it is important to study the influence of the thermal process on drug release in emerging technologies such as 3D printing-fused deposition modeling (FDM). For this purpose, the characteristics of 3D printed tablets were compared to those of tablets prepared by other thermal methods such as hot-melt extrusion (HME) and non-thermal methods such as physical mixture (PM). Theophylline was used as a drug model and blends of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) were used as a matrix former. The solid state of the drug in all formulations was investigated by differential scanning calorimetry, X-ray powder diffraction, and Fourier-transformed infrared spectroscopy. All studied tablets had the same weight and surface area/volume (SA/V). Dissolution data showed that, for some formulations, printed tablets interestingly had a faster release profile despite having the highest hardness values (>550 N) compared to HME and PM tablets. Porosity investigations showed that 100% infill printed tablets had the highest porosity (~20%) compared to HME (<10%) and PM tablets (≤11%). True density records were the lowest in printed tablets (~1.22 g/m3) compared to tablets made from both HME and PM methods (~1.26 g/m3), reflecting the possible increase in polymer specific volume while printing. This increase in the volume of polymer network may accelerate water and drug diffusion from/within the matrix. Thus, it is a misconception that the 3D printing process will always retard drug release based on increased tablet hardness. Hardness, porosity, density, solid-state of the drug, SA/V, weight, and formulation components are all factors contributing to the release profile where the total balance can either slow down or accelerate the release profile.Citation
Nashed N, Lam M, Ghafourian T, Pausas L, Jiri M, Majumder M, Nokhodchi A (2022) 'An insight into the impact of thermal process on dissolution profile and physical characteristics of theophylline tablets made through 3D printing compared to conventional methods', Biomedicines, 10 (6), pp.1335-.Publisher
MDPIJournal
BiomedicinesPubMed ID
35740357Additional Links
https://www.mdpi.com/2227-9059/10/6/1335Type
ArticleLanguage
enISSN
2227-9059ae974a485f413a2113503eed53cd6c53
10.3390/biomedicines10061335
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
Related articles
- Effect of pH, Ionic Strength and Agitation Rate on Dissolution Behaviour of 3D-Printed Tablets, Tablets Prepared from Ground Hot-Melt Extruded Filaments and Physical Mixtures.
- Authors: Nashed N, Chan S, Lam M, Ghafourian T, Nokhodchi A
- Issue date: 2023 Jan 27
- Development of immediate release 3D-printed dosage forms for a poorly water-soluble drug by fused deposition modeling: Study of morphology, solid state and dissolution.
- Authors: Fanous M, Bitar M, Gold S, Sobczuk A, Hirsch S, Ogorka J, Imanidis G
- Issue date: 2021 Apr 15
- Simplification of fused deposition modeling 3D-printing paradigm: Feasibility of 1-step direct powder printing for immediate release dosage form production.
- Authors: Fanous M, Gold S, Muller S, Hirsch S, Ogorka J, Imanidis G
- Issue date: 2020 Mar 30
- A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets.
- Authors: Okwuosa TC, Stefaniak D, Arafat B, Isreb A, Wan KW, Alhnan MA
- Issue date: 2016 Nov
- Development of multiple structured extended release tablets via hot melt extrusion and dual-nozzle fused deposition modeling 3D printing.
- Authors: Zhang P, Li J, Ashour EA, Chung S, Wang H, Vemula SK, Repka MA
- Issue date: 2024 Feb 13