Bi-layered disulfiram-loaded fiber membranes with antibacterial properties for wound dressing
Authors
Xie, ChenchenYan, Jin
Cao, Siyuan
Liu, Ri
Sun, Baishun
Xie, Ying
Qu, Kaige
Zhang, Wenxiao
Weng, Zhankun
Wang, Zuobin
Issue Date
2021-10-29Subjects
bi-layered disulfiram-loaded fiber membranesantibacterial activity
surface wettability
electrospinning
wound dressing
Subject Categories::C560 Biotechnology
Metadata
Show full item recordAbstract
In this study, the bi-layered disulfiram-loaded fiber membranes with the antibacterial activity and different surface wettabilities are prepared using electrospinning technology. In the application of wound dressing, the hydrophilic surface of fiber membranes is beneficial for cell adhesion and drug release to heal the wound. Meanwhile, the outside hydrophobic surface is able to block water penetration to reduce the probability of wound infection. The obtained bi-layered drug-loaded fiber membranes are composed of polyvinylidene fluoride (PVDF) bottom surface and disulfiram (DSF)/polylactic acid (PLA) top surface. To modify the top surface wettability, the oxygen plasma modification of bi-layered membranes was carried out. The morphology, wettability, and chemical compositions of bi-layered drug-loaded fiber membranes were analyzed using the scanning electronic microscope (SEM), drop shape analysis instrument, X-ray diffractometer (XRD), and X-ray photoelectron spectrometer (XPS). The bi-layered disulfiram-loaded membranes showed the potent antibacterial activity in vitro against both Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive). It was found that the bi-layered membranes had good biocompatibility with L929 cells. Thus, the obtained bi-layered disulfiram-loaded fiber membranes are suitable for wound dressing application.Citation
Xie C, Yan J, Cao S, Liu R, Sun B, Xie Y, Qu K, Zhang W, Weng Z, Wang Z (2022) 'Bi-layered disulfiram-loaded fiber membranes with antibacterial properties for wound dressing', Applied Biochemistry and Biotechnology, 194 (3), pp.1359-1372.Publisher
SpringerPubMed ID
34714499Additional Links
https://link.springer.com/article/10.1007/s12010-021-03663-0Type
ArticleLanguage
enISSN
0273-2289EISSN
1559-0291Sponsors
This work was supported by the National Key R&D Program of China (No. 2017YFE0112100), EU H2020 Program (MNR4SCell No. 734174; NanoStencil No. 767285), Jilin Provincial Science and Technology Program (Nos. 20180414002GH, 20180414081GH, 20180520203JH, 20190702002GH, and 20200901011SF), Jilin Provincial DRC Research and Development Program (No. 2020C022-1), and “111” Project of China (No. D17017).ae974a485f413a2113503eed53cd6c53
10.1007/s12010-021-03663-0
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