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dc.contributor.authorSaad, Sadiq M.
dc.contributor.authorIwundu, Chukwuma
dc.contributor.authorIbrahim, Musa Saulawa
dc.contributor.authorRandhawa, Gurch
dc.contributor.authorPang, Dong
dc.contributor.illustrator
dc.date.accessioned2022-04-21T11:38:26Z
dc.date.available2022-03-29T00:00:00Z
dc.date.available2022-04-21T11:38:26Z
dc.date.issued2022-03-29
dc.identifier.citationSaad SM, Iwundu C, Ibrahim MS, Randhawa G, Pang D (2022) 'Life-course influence of adolescent behaviour problems on type 2 diabetes in midlife: results from 1958 British Birth Cohort Study', Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 15, pp.963-972.en_US
dc.identifier.issn1178-7007
dc.identifier.pmid35378832
dc.identifier.doi10.2147/DMSO.S308620
dc.identifier.urihttp://hdl.handle.net/10547/625374
dc.description.abstractTo assess whether there is a long-term relationship between childhood behaviour problems and type 2 diabetes in midlife. The study will also investigate whether any of such relationship is independent of other factors which may be associated with type 2 diabetes. Cohort study. A total of 9377 members of the 1958 British birth cohort participated in the biomedical survey at age 45 years. The cohort has been followed up at regular intervals in childhood (age 7, 11 and 16 years) and adulthood (23, 33, 42 and 45 years). Information regarding childhood behaviour collected during follow-ups at ages 7, 11 and 16 years. Type 2 diabetes assessed using HbA1c at age 45 years. Unadjusted estimates show that teachers reported adolescent behaviour problems at age of 16 are associated with increased risk of type 2 diabetes in midlife. After adjustment for potential confounders and mediators in childhood and adulthood, a relationship was observed between the severity of adolescent behaviour problems and type 2 diabetes risk in midlife (mild behaviour problems: OR 2.17, 95% CI 1.11-4.23; severe behaviour problems: OR 4.40, 95% CI 1.14-16.99). However, no such relationship was observed between behaviour problems at 7 and 11 years and type 2 diabetes in midlife. There is an association between adolescent behaviour problems and an increased risk of type 2 diabetes in midlife. Further molecular/genetic studies are required to understand the biological basis for this observed association.en_US
dc.description.sponsorshipNo funding received.en_US
dc.language.isoenen_US
dc.publisherDove Pressen_US
dc.relation.urlhttps://www.dovepress.com/life-course-influence-of-adolescent-behaviour-problems-on-type-2-diabe-peer-reviewed-fulltext-article-DMSOen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject1958 British birth cohorten_US
dc.subjectHbA1cen_US
dc.subjectnational child development studyen_US
dc.subjectadolescent behaviour problemsen_US
dc.subjecttype 2 diabetesen_US
dc.subjectSubject Categories::C841 Health Psychologyen_US
dc.titleLife-course influence of adolescent behaviour problems on type 2 diabetes in midlife: results from 1958 British Birth Cohort Studyen_US
dc.typeArticleen_US
dc.identifier.eissn1178-7007
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journalDiabetes, Metabolic Syndrome and Obesity: Targets and Therapyen_US
dc.identifier.pmcidPMC8976514
dc.date.updated2022-04-21T11:33:26Z
dc.description.notegold open access


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International