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dc.contributor.authorLi, Pengfei
dc.contributor.authorGao, Yanyan
dc.contributor.authorMa, Xiaojun
dc.contributor.authorZhou, Shaobo
dc.contributor.authorGuo, Yujie
dc.contributor.authorXu, Jingjing
dc.contributor.authorWang, Xixiang
dc.contributor.authorVan Halm-Lutterodt, Nicholas
dc.contributor.authorYuan, Linhong
dc.date.accessioned2022-04-13T12:20:12Z
dc.date.available2022-03-31T00:00:00Z
dc.date.available2022-04-13T12:20:12Z
dc.date.issued2022-03-31
dc.identifier.citationLi P, Gao Y, Ma X, Zhou S, Guo Y, Xu J, Wang X, Van Halm-Lutterodt N, Yuan L (2022) 'Study on the association of dietary fatty acids intake and serum lipid profiles with cognition in aging subjects with type 2 diabetes mellitus', Frontiers in Aging Neuroscience, 14 (846132)en_US
dc.identifier.issn1663-4365
dc.identifier.pmid35431907
dc.identifier.doi10.3389/fnagi.2022.846132
dc.identifier.urihttp://hdl.handle.net/10547/625368
dc.description.abstractBackground: The correlation between dietary fatty acid (FA) intake and serum lipid profile levels with cognition in the aged population has been reported by previous studies. However, the association of dietary FA intake and serum lipid profile levels with cognition in subjects with type 2 diabetes mellitus (T2DM) is seldom reported. Objective: A cross-sectional study was conducted to explore the correlation between dietary FA intake and serum lipid profiles with cognition in the aged Chinese population with T2DM. Methods: A total of 1,526 aged Chinese subjects were recruited from communities. Fasting blood samples were collected for parameter measurement. The food frequency questionnaire (FFQ) method was applied for a dietary survey. Cognition was assessed using the Montreal Cognitive Assessment (MoCA) test. Dietary FA intake and serum lipid levels were compared between subjects with T2DM and control subjects. A logistic regression analysis was carried out for analyzing the association of FA intake and serum lipid levels with the risk of mild cognitive impairment (MCI) in subjects with T2DM and control subjects. Results: There was a significant difference in the serum lipid level between the T2DM group and the control group. Results of the logistic regression analysis demonstrated the potential associations of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and dietary n-3 polyunsaturated fatty acids (PUFAs) intake with the risk of MCI in subjects with T2DM, but the associations were not observed in control subjects. Conclusion: The T2DM phenotype might affect the relationship between dietary FA intake, circulating lipids, and cognitive performance. Large prospective cohort studies are needed to uncover the underlying mechanism of how dietary FA intake and serum lipid levels affect cognition in aged subjects with T2DM.en_US
dc.description.sponsorshipThis study was supported by grants from the National Natural Science Foundation of China (Nos. 81973027 and 82173508).en_US
dc.language.isoenen_US
dc.publisherFrontiersen_US
dc.relation.urlhttps://www.frontiersin.org/articles/10.3389/fnagi.2022.846132/fullen_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjecttype 2 diabetes mellitusen_US
dc.subjecttype 2 diabetesen_US
dc.subjectdiabetes mellitusen_US
dc.subjectdietary fatty acidsen_US
dc.subjectcognitionen_US
dc.subjectSubject Categories::B140 Neuroscienceen_US
dc.titleStudy on the association of dietary fatty acids intake and serum lipid profiles with cognition in aging subjects with type 2 diabetes mellitusen_US
dc.typeArticleen_US
dc.contributor.departmentCapital Medical University, Beijingen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.contributor.departmentBrown Universityen_US
dc.identifier.journalFrontiers in Aging Neuroscienceen_US
dc.identifier.pmcidPMC9009143
dc.date.updated2022-04-13T12:13:26Z
dc.description.notegold oa


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