Study on the association of dietary fatty acids intake and serum lipid profiles with cognition in aging subjects with type 2 diabetes mellitus
Authors
Li, PengfeiGao, Yanyan
Ma, Xiaojun
Zhou, Shaobo
Guo, Yujie
Xu, Jingjing
Wang, Xixiang
Van Halm-Lutterodt, Nicholas
Yuan, Linhong
Issue Date
2022-03-31Subjects
type 2 diabetes mellitustype 2 diabetes
diabetes mellitus
dietary fatty acids
cognition
Subject Categories::B140 Neuroscience
Metadata
Show full item recordAbstract
Background: The correlation between dietary fatty acid (FA) intake and serum lipid profile levels with cognition in the aged population has been reported by previous studies. However, the association of dietary FA intake and serum lipid profile levels with cognition in subjects with type 2 diabetes mellitus (T2DM) is seldom reported. Objective: A cross-sectional study was conducted to explore the correlation between dietary FA intake and serum lipid profiles with cognition in the aged Chinese population with T2DM. Methods: A total of 1,526 aged Chinese subjects were recruited from communities. Fasting blood samples were collected for parameter measurement. The food frequency questionnaire (FFQ) method was applied for a dietary survey. Cognition was assessed using the Montreal Cognitive Assessment (MoCA) test. Dietary FA intake and serum lipid levels were compared between subjects with T2DM and control subjects. A logistic regression analysis was carried out for analyzing the association of FA intake and serum lipid levels with the risk of mild cognitive impairment (MCI) in subjects with T2DM and control subjects. Results: There was a significant difference in the serum lipid level between the T2DM group and the control group. Results of the logistic regression analysis demonstrated the potential associations of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), and dietary n-3 polyunsaturated fatty acids (PUFAs) intake with the risk of MCI in subjects with T2DM, but the associations were not observed in control subjects. Conclusion: The T2DM phenotype might affect the relationship between dietary FA intake, circulating lipids, and cognitive performance. Large prospective cohort studies are needed to uncover the underlying mechanism of how dietary FA intake and serum lipid levels affect cognition in aged subjects with T2DM.Citation
Li P, Gao Y, Ma X, Zhou S, Guo Y, Xu J, Wang X, Van Halm-Lutterodt N, Yuan L (2022) 'Study on the association of dietary fatty acids intake and serum lipid profiles with cognition in aging subjects with type 2 diabetes mellitus', Frontiers in Aging Neuroscience, 14 (846132)Publisher
FrontiersJournal
Frontiers in Aging NeurosciencePubMed ID
35431907PubMed Central ID
PMC9009143Additional Links
https://www.frontiersin.org/articles/10.3389/fnagi.2022.846132/fullType
ArticleLanguage
enISSN
1663-4365Sponsors
This study was supported by grants from the National Natural Science Foundation of China (Nos. 81973027 and 82173508).ae974a485f413a2113503eed53cd6c53
10.3389/fnagi.2022.846132
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Green - can archive pre-print and post-print or publisher's version/PDF
Related articles
- Association of ApoE Genetic Polymorphism and Type 2 Diabetes with Cognition in Non-Demented Aging Chinese Adults: A Community Based Cross-Sectional Study.
- Authors: Zhen J, Lin T, Huang X, Zhang H, Dong S, Wu Y, Song L, Xiao R, Yuan L
- Issue date: 2018 Jun
- Association of Circulating Retinol and α-TOH Levels with Cognitive Function in Aging Subject with Type 2 Diabetes Mellitus.
- Authors: Huang X, Guo Y, Li P, Ma X, Dong S, Hu H, Li Y, Yuan L
- Issue date: 2020
- Age Related Prevalence of Mild Cognitive Impairment in Type 2 Diabetes Mellitus Patients in the Indian Population and Association of Serum Lipids With Cognitive Dysfunction.
- Authors: Chakraborty A, Hegde S, Praharaj SK, Prabhu K, Patole C, Shetty AK, Mayya SS, Acharya RV, Hande HM, Prabhu MM, Upadhya D
- Issue date: 2021
- The Erythrocyte Fatty Acid Profile and Cognitive Function in Old Chinese Adults.
- Authors: Yuan L, Zhen J, Ma W, Cai C, Huang X, Xiao R
- Issue date: 2016 Jun 23
- [Correlation analysis of lipid level and cognitive function in middle-aged and elderly diabetic population from 2 communities in Beijing in 2017].
- Authors: Zhang H, Li P, Guo Y, Ma X, Xu J, Yuan L
- Issue date: 2022 Nov