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dc.contributor.authorHu, Yu
dc.contributor.authorWang, Shu-Xiang
dc.contributor.authorWu, Fu-Yu
dc.contributor.authorWu, Ke-Jia
dc.contributor.authorShi, Rui-Ping
dc.contributor.authorQin, Li-Hong
dc.contributor.authorLu, Chun-Feng
dc.contributor.authorWang, Shu-Qiu
dc.contributor.authorWang, Fang-Fang
dc.contributor.authorZhou, Shaobo
dc.contributor.illustrator
dc.date.accessioned2022-04-13T11:25:04Z
dc.date.available2022-03-08T00:00:00Z
dc.date.available2022-04-13T11:25:04Z
dc.date.issued2022-03-08
dc.identifier.citationHu Y, Wang S-X, Wu F-Y, Wu K-J, Shi R-P, Qin L-H, Lu C-F, Wang S-Q, Wang F-F, Zhou S (2022) 'Effects and mechanism of Ganoderma lucidum polysaccharides in the treatment of diabetic nephropathy in streptozotocin-induced diabetic rats', BioMed Research International, 2022 (4314415)en_US
dc.identifier.issn2314-6133
dc.identifier.pmid35299891
dc.identifier.doi10.1155/2022/4314415
dc.identifier.urihttp://hdl.handle.net/10547/625367
dc.description.abstractGanoderma lucidum polysaccharides (GLP) have renal protection effect but there was no study on the diabetic nephropathy. This study was designed to investigate its effect and mechanism using a diabetic rat model induced by streptozotocin (50 mg/kg, i.p.). The diabetic rats were treated with GLP (300 mg/kg/day) for 10 weeks. The blood glucose, glycated hemoglobin, body weight, and the levels of blood creatinine, urea nitrogen, and urine protein were assessed. And renal pathologies were assessed by the tissue sections stained with hematoxylin-eosin, Masson’s trichome, and periodic acid-Schiff. The expression of phosphorylated phosphoinositide 3 kinase (p-PI3K), phosphorylated protein kinase B (p-Akt), and phosphorylated mammalian target of rapamycin (p-mTOR), the autophagy proteins beclin-1, LC3-II, LC3-I, and P62; the apoptosis-related proteins caspase-3 and caspase-9; and the inflammation markers IL-6, IL-1β, and TNF-ɑ were assessed. Results showed that GLP alleviated the impairment of renal function by reducing urinary protein excretion and the blood creatinine level and ameliorated diabetic nephropathy. The expression of p-PI3K, p-Akt, and p-mTOR in the diabetic kidney were significantly reduced in the GLP treatment group compared to the without treatment group. GLP treatment activated the autophagy indicators of beclin-1 and the ratio of LC3-II/LC3-I but reduced p62 and also inhibited the expression of caspase-3, caspase-9 and IL-6, IL-1β, and TNF-ɑ. In conclusion, the effect of GLP amelioration diabetic nephropathy may be via the PI3k/Akt/mTOR signaling pathway by inhibition of the apoptosis and inflammation and activation of the autophagy process.en_US
dc.language.isoenen_US
dc.publisherHindawien_US
dc.relation.urlhttps://www.hindawi.com/journals/bmri/2022/4314415/en_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectGanoderma lucidum polysaccharidesen_US
dc.subjectdiabetes mellitusen_US
dc.subjectSubject Categories::C131 Applied Cell Biologyen_US
dc.titleEffects and mechanism of Ganoderma lucidum polysaccharides in the treatment of diabetic nephropathy in streptozotocin-induced diabetic ratsen_US
dc.typeArticleen_US
dc.contributor.departmentJiamusi Universityen_US
dc.contributor.departmentHuzhou Central Hospitalen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journalBioMed Research Internationalen_US
dc.identifier.pmcidPMC8923773
dc.date.updated2022-04-13T10:54:10Z
dc.description.notegold oa


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