Analysis of the mechanical properties of chromosomes in air and liquid by AFM
AffiliationChangchun University of Science and Technology
Changli Nano Biotechnology Ltd
University of Bedfordshire
Subjectsatomic force microscopy
Subject Categories::J990 Technologies not elsewhere classified
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AbstractChromosomes contain all the genomic information thus making the study of chromosomes practical and significant. Herein, the morphologies of chromosomes prepared with different methods were monitored by atomic force microscopy (AFM). Moreover, the mechanical properties of chromosomes in air and liquid were investigated quantitatively through AFM-based force spectroscopy. The differences of chromosome morphologies and mechanical properties caused by sample preparations indicated that the chromosome characterization in liquid was more meaningful to reveal the physiological characteristics of chromosomes.
CitationWang B, Yang F, Dong J, Li J, Wang Y, Qu K, Wei H, Wang Z (2021) 'Analysis of the mechanical properties of chromosomes in air and liquid by AFM', 2021 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) - Xi'an, China, .
TypeConference papers, meetings and proceedings
SponsorsThis work was supported by National Key R&D Program of China (No. 2017YFE0112100), EU H2020 Program MNR4SCell No. 734174; NanoStencil No. 767285), Jilin Provincial Science and Technology Program (Nos. 2020C022-1, 20190201287JC, 20190702002GH and 20200901011SF), Jilin Province Education Department Program (Nos. JJKH20210833KJ), and “111” Project of China (No. D17017).
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