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dc.contributor.authorJu, Tuoyu
dc.contributor.authorYang, Fan
dc.contributor.authorWang, Ying
dc.contributor.authorSong, Zhengxun
dc.contributor.authorXu, Hongmei
dc.contributor.authorChen, Yujuan
dc.contributor.authorWang, Zuobin
dc.date.accessioned2022-03-17T10:23:17Z
dc.date.available2022-03-17T00:00:00Z
dc.date.available2022-03-17T10:23:17Z
dc.date.issued2021-11-18
dc.identifier.citationJu T, Yang F, Wang Y, Song Z, Xu H, Chen Y, Wang Z (2021) 'Effect of SMMC-7721-derived exosomes on hepatocytes studied by AFM', 2021 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) - Xi'an, China, IEEE.en_US
dc.identifier.isbn9781665448826
dc.identifier.doi10.1109/3M-NANO49087.2021.9599805
dc.identifier.urihttp://hdl.handle.net/10547/625347
dc.description.abstractExosomes play an important role in the early diagnosis and development of hepatocellular carcinoma (HCC). In the past, researchers mainly studied the contents of exosomes and the biological mechanism on cells, but the changes of mechanical properties of cells caused by exosomes are not clear. In this study, the changes of mechanical properties of hepatocytes (L-02) co-cultured with exosomes (7721-exos) derived from HCC (SMMC-7721) with low metastatic ability were studied. The 7721-exos were able to promote the proliferation and rearrange the cytoskeleton of L-02 cells. The atomic force microscopy measurement results showed that the height was increased, the adhesion and the elastic modulus were reduced. The effect was concentration dependent. The changes of cell mechanical properties induced by exosomes were of great significance for further studying the mechanism of exosomes.en_US
dc.description.sponsorshipThis work was supported by National Key R&D Program of China (No. 2017YFE0112100), EU H2020 Program (MNR4SCell No. 734174), National Natural Science Foundation Program of China (No. 62175020), Jilin Provincial Science and Technology Program (Nos. 2020C022-1, 20190201287JC, 20190702002GH and 20200901011SF), Jilin Province Education Department Program (No. JJKH20210833KJ), and “111” Project of China (No. D17017). It was partly supported by Changli Nano Biotechnology (China).en_US
dc.language.isoenen_US
dc.publisherIEEEen_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectexosomesen_US
dc.subjecthepatocytesen_US
dc.subjectatomic force microscopyen_US
dc.subjectSubject Categories::J990 Technologies not elsewhere classifieden_US
dc.titleEffect of SMMC-7721-derived exosomes on hepatocytes studied by AFMen_US
dc.typeConference papers, meetings and proceedingsen_US
dc.contributor.departmentChangchun University of Science and Technologyen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.date.updated2022-03-17T10:18:31Z
dc.description.noteDate of acceptance: 1/7/2021 Electronic ISSN: 2694-510X Print on Demand(PoD) ISSN: 2373-5422 see http://conferences.ieeeauthorcenter.ieee.org/wp-content/uploads/sites/8/IEEE-Conference-Paper-Sharing-and-Posting-Policies.pdf authors may post accepted version to repositories


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