Single enrichment systems possibly underestimate both exposures and biological effects of organic pollutants from drinking water
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Authors
Yang, LanZhou, Ying
Chen, Li
Chen, Hanyi
Liu, Wenhao
Zheng, Weiwei
Andersen, Melvin E.
Zhang, Yubing
Hu, Yi
Crabbe, M. James C.
Qu, Weidong
Issue Date
2022-01-03Subjects
pollutiondrinking-water
water quality
water contamination
Subject Categories::H122 Water Quality Control
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Comprehensive enrichment of contaminants in drinking water is an essential step for accurately determining exposure levels of contaminants and testing their biological effects. Traditional methods using a single absorbent for enriching contaminants in water might not be adequate for complicated matrices with different physical-chemical profiles . To examine this hypothesis, we used an integrated enrichment system that had three sequential stages-XAD-2 resin, poly (styrene–divinylbenzene) and activated charcoal to capture organic pollutants and disinfection by-products (DBPs) from drinking water in Shanghai. Un-adsorbed Organic Compounds in Eluates (UOCEs) named UOCEs-A, -B, and-C following each adsorption stage were determined by gas chromatography-mass spectromet ry to evaluate adsorption efficiency of the enrichment system . Meanwhile, biological effects such as cytotoxicity, effects on reactive oxygen species (ROS) generation and glutathione (GSH) depletion were determined in human LO2 cells to identify potential adverse effects on exposure to low dose contaminants. We found that poly-styrene–divinylbenzene (PS-DVB) and activated charcoal (AC) could still partly collect UOCEs-A and-B that the upper adsorption column incompletely captured, and that potential carcinogens like 2- naphthamine were present in all eluates. UOCEs-A at (1-4000), UOCEs-B at (1000-4000), and UOCEs-C at (2400-4000) folds of the actual concentrations had significant cytotoxicity to LO2 cells. Additionally, ROS and GSH change in cells treated with UOCEs indicated the potential for long-term effects of exposure to some mixtures of contaminants such as DBPs at low doses . These results suggested that an enriching system with a single adsorbent would underestimate the exposure level of pollutants and the biological effects of organic pollutants from drinking water. Effective methods for pollutants’ enrichment and capture of drinking water should be given priority in future studies on accurate evaluation of biological effects exposed to mixed pollutants via drinking water.Citation
Yang L, Zhou Y, Chen L, Chen H, Liu W, Zheng W, Andersen ME, Zhang Y, Hu Y, Crabbe MJC, Qu W (2022) 'Single enrichment systems possibly underestimate both exposures and biological effects of organic pollutants from drinking water', Chemosphere, 292, 133496.Publisher
ElsevierJournal
ChemospherePubMed ID
34990717Type
ArticleLanguage
enISSN
0045-6535Sponsors
This research was supported by grants from National Natural Science Fund Committee [No. 81630088, 81930094 & 81325017], Changjiang Scholars Program, Chinese Ministry of Education [T2014089], Shanghai Municipal Health Bureau Three Years Action Plan [No. 08GWD14], and Leadership Project [No. 2017] Leadership Project of Shanghai Municipal Government, National Key Basic Research Program of China [No. 2017YFC1600200], and Natural High- Technology R&D 863 Program [No. 2013AA065204].ae974a485f413a2113503eed53cd6c53
10.1016/j.chemosphere.2021.133496
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