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dc.contributor.authorNokhodchi, Ali
dc.contributor.authorGhafourian, Taravat
dc.contributor.authorNashed, Nour
dc.contributor.authorAsare-Addo, Kofi
dc.contributor.authorBehboudi, Elmira
dc.contributor.authorSefid-Sefidehkhan, Yasaman
dc.contributor.authorZarghampour, Aynaz
dc.contributor.authorRahimpour, Elaheh
dc.contributor.authorJouyban, Abolghasem
dc.contributor.illustrator
dc.date.accessioned2022-01-05T09:25:06Z
dc.date.available2021-12-28T00:00:00Z
dc.date.available2022-01-05T09:25:06Z
dc.date.issued2021-12-28
dc.identifier.citationNokhodchi A, Ghafourian T, Nashed N, Asare-Addo K, Behboudi E, Sefid-Sefidehkhan Y, Zarghampour A, Rahimpour E, Jouyban A (2022) 'Solubility study of acetylsalicylic acid in ethanol + water mixtures: measurement, mathematical modeling, and stability Discussion', AAPS PharmSciTech, 23 (1), pp.42-.en_US
dc.identifier.pmid34964076
dc.identifier.doi10.1208/s12249-021-02192-7
dc.identifier.urihttp://hdl.handle.net/10547/625281
dc.description.abstractSolubility determination of poorly water-soluble drugs is pivotal for formulation scientists when they want to develop a liquid formulation. Performing such a test with different ratios of cosolvents with water is time-consuming and costly. The scarcity of solubility data for poorly water-soluble drugs increases the importance of developing correlation and prediction equations for these mixtures. Therefore, the aim of the current research is to determine the solubility of acetylsalicylic acid in binary mixtures of ethanol+water at 25 and 37°C. Acetylsalicylic acid is non-stable in aqueous solutions and readily hydrolyze to salicylic acid. So, the solubility of acetylsalicylic acid is measured in ethanolic mixtures by HPLC to follow the concentration of produced salicylic acid as well. Moreover, the solubility of acetylsalicylic acid is modeled using different cosolvency equations. The measured solubility data were also predicted using PC-SAFT EOS model. DSC results ruled out any changes in the polymorphic form of acetylsalicylic acid after the solubility test, whereas XRPD results showed some changes in crystallinity of the precipitated acetylsalicylic acid after the solubility test. Fitting the solubility data to the different cosolvency models showed that the mean relative deviation percentage for the Jouyban-Acree model was less than 10.0% showing that this equation is able to obtain accurate solubility data for acetylsalicylic acid in mixtures of ethanol and water. Also, the predicted data with an average mean relative deviation percentage (MRD%) of less than 29.65% show the capability of the PC-SAFT model for predicting solubility data. A brief comparison of the solubilities of structurally related solutes to acetylsalicylic acid was also provided.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.urlhttps://link.springer.com/article/10.1208%2Fs12249-021-02192-7en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectacetylsalicylic aciden_US
dc.subjectsolubility predictionen_US
dc.subjectthermal analysisen_US
dc.subjectethanolen_US
dc.subjectPC-SAFT EOSen_US
dc.subjectSubject Categories::B210 Pharmacologyen_US
dc.titleSolubility study of acetylsalicylic acid in ethanol + water mixtures: measurement, mathematical modeling, and stability discussionen_US
dc.typeArticleen_US
dc.identifier.eissn1530-9932
dc.identifier.journalAAPS PharmSciTechen_US
dc.date.updated2022-01-05T00:00:32Z
dc.description.notegold oa


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International