Solubility study of acetylsalicylic acid in ethanol + water mixtures: measurement, mathematical modeling, and stability discussion
Authors
Nokhodchi, AliGhafourian, Taravat
Nashed, Nour
Asare-Addo, Kofi
Behboudi, Elmira
Sefid-Sefidehkhan, Yasaman
Zarghampour, Aynaz
Rahimpour, Elaheh
Jouyban, Abolghasem
Issue Date
2021-12-28Subjects
acetylsalicylic acidsolubility prediction
thermal analysis
ethanol
PC-SAFT EOS
Subject Categories::B210 Pharmacology
Metadata
Show full item recordAbstract
Solubility determination of poorly water-soluble drugs is pivotal for formulation scientists when they want to develop a liquid formulation. Performing such a test with different ratios of cosolvents with water is time-consuming and costly. The scarcity of solubility data for poorly water-soluble drugs increases the importance of developing correlation and prediction equations for these mixtures. Therefore, the aim of the current research is to determine the solubility of acetylsalicylic acid in binary mixtures of ethanol+water at 25 and 37°C. Acetylsalicylic acid is non-stable in aqueous solutions and readily hydrolyze to salicylic acid. So, the solubility of acetylsalicylic acid is measured in ethanolic mixtures by HPLC to follow the concentration of produced salicylic acid as well. Moreover, the solubility of acetylsalicylic acid is modeled using different cosolvency equations. The measured solubility data were also predicted using PC-SAFT EOS model. DSC results ruled out any changes in the polymorphic form of acetylsalicylic acid after the solubility test, whereas XRPD results showed some changes in crystallinity of the precipitated acetylsalicylic acid after the solubility test. Fitting the solubility data to the different cosolvency models showed that the mean relative deviation percentage for the Jouyban-Acree model was less than 10.0% showing that this equation is able to obtain accurate solubility data for acetylsalicylic acid in mixtures of ethanol and water. Also, the predicted data with an average mean relative deviation percentage (MRD%) of less than 29.65% show the capability of the PC-SAFT model for predicting solubility data. A brief comparison of the solubilities of structurally related solutes to acetylsalicylic acid was also provided.Citation
Nokhodchi A, Ghafourian T, Nashed N, Asare-Addo K, Behboudi E, Sefid-Sefidehkhan Y, Zarghampour A, Rahimpour E, Jouyban A (2022) 'Solubility study of acetylsalicylic acid in ethanol + water mixtures: measurement, mathematical modeling, and stability Discussion', AAPS PharmSciTech, 23 (1), pp.42-.Journal
AAPS PharmSciTechPubMed ID
34964076Additional Links
https://link.springer.com/article/10.1208%2Fs12249-021-02192-7Type
ArticleLanguage
enEISSN
1530-9932ae974a485f413a2113503eed53cd6c53
10.1208/s12249-021-02192-7
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