Proteins and disease | Structural insight and functional diversity of mammalian fatty acid binding proteins in health and disease
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Encyclopedia of Biological Chemistry IIIAbstract
The mammalian Fatty Acid-Binding Protein (FABP) family consists of 9 members, each displaying a β barrel capped by 2 short α-helices. The FABPs exhibit distinct and overlapping tissue expression patterns and bind long chain fatty acids with high affinity. The FABPs use interactions with membranes and proteins to transport fatty acids to sites of utilization, and each FABP displays distinct tissue specific functions. Recently several FABPs have been shown to bind additional lipid ligands, notably endocannabinoids, and to exert systemic functions remote from their tissues of origin. Some FABPs are dysregulated in cancer and inflammatory diseases, offering potential as drug targets and biomarkers.Citation
McDermott LC, Storch J (2021) 'Proteins and disease | Structural insight and functional diversity of mammalian fatty acid binding proteins in health and disease', in Jez J (ed.). Encyclopedia of Biological Chemistry III, 3rd edn, : Elsevier pp.63-76.Publisher
ElsevierType
Book chapterLanguage
enISBN
9780128194607ae974a485f413a2113503eed53cd6c53
10.1016/B978-0-12-819460-7.00173-0