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dc.contributor.authorYan, Jin
dc.contributor.authorCao, Liang
dc.contributor.authorWang, Lu
dc.contributor.authorXie, Chengcheng
dc.contributor.authorLiu, Yan
dc.contributor.authorSong, Zhengxun
dc.contributor.authorXu, Hongmei
dc.contributor.authorWeng, Zhankun
dc.contributor.authorWang, Zuobin
dc.contributor.authorLi, Li
dc.date.accessioned2021-03-17T12:38:08Z
dc.date.available2021-03-17T12:38:08Z
dc.date.issued2021-02-22
dc.identifier.citationYan J, Cao L, Wang L, Xie C, Liu Y, Song Z, Xu H, Weng Z, Wang Z, Li L (2021) 'Response of bEnd.3 cells to growing behavior on the graphene oxide film with 2-D grating structure by two-beam laser interference', Applied Nanoscience, 11 , pp.1141-1149.en_US
dc.identifier.issn2190-5509
dc.identifier.doi10.1007/s13204-021-01701-1
dc.identifier.urihttp://hdl.handle.net/10547/624891
dc.description.abstractGraphene (G) and its derivatives are important nanomaterials with potential medical applications for biosensors and implanting biomaterials. The hydrophobicity and surface microstructures of substrates have great influences on the biological and physical properties of the surface-bound cells. In this work, we used the two-beam laser interference (TBLI) technique to prepare a two-dimensional (2-D) grating structure on the surface of graphene oxide (GO) film. We investigated the effect of GO and the GO film with the 2-D grating structure substrates on the growth behavior of rat brain microvascular endothelial (bEnd.3) cells. The results demonstrated that the cell spreading area and the number of surface-bound cells were closely related to the hydrophobicity of the substrate and the presence of oxygen-containing functional groups (OCGs). Due to the interaction of laser and GO, the GO in the interference area was transformed into reduced graphene oxide (RGO). The grating-structured GO film significantly affected the direction of cell spreading and morphology. It has a good application prospect as a scaffold in tissue engineering, and promising applications in the fields that require highly directional growth of cells, such as nerve injury repair, tendon repair and regeneration.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.urlhttps://link.springer.com/article/10.1007%2Fs13204-021-01701-1en_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.subjectgraphene oxideen_US
dc.subjectoxygen-containing functional groupsen_US
dc.subjectreduced graphene oxideen_US
dc.subjecttwo-beam laser interferenceen_US
dc.titleResponse of bEnd.3 cells to growing behavior on the graphene oxide film with 2-D grating structure by two-beam laser interferenceen_US
dc.typeArticleen_US
dc.identifier.eissn2190-5517
dc.identifier.journalApplied Nanoscienceen_US
dc.date.updated2021-03-17T12:34:39Z
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