Liqui-pellet: the emerging next-generation oral dosage form which stems from liquisolid concept in combination with pelletization technology
Issue Date
2019-06-24Subjects
liquisolidnaproxen
powder flow
dissolution enhancement
liqui-pellet
solid state analysis
Subject Categories::H812 Pharmaceutical Engineering
Metadata
Show full item recordAbstract
In spite of the major advantages that the liquisolid technology offers, particularly in tackling poor bioavailability of poorly water-soluble drugs (i.e., BCS Class II drugs), there are a few critical drawbacks. The inability of a high liquid load factor, poor flowability, poor compactibility, and an inability to produce a high dose dosage form of a reasonable size for swallowing are major hurdles, hampering this technology from being commercially feasible. An attempt was therefore made to overcome these drawbacks whilst maintaining the liquisolid inherent advantages. This resulted in the emerging next generation of oral dosage forms called the liqui-pellet. All formulations were incorporated into capsules as the final product. Solubility studies of naproxen were conducted in different liquid vehicles, namely polyethylene glycol 200, propylene glycol, Tween 80, Labrafil, Labrasol, and Kolliphor EL. The scanning electron microscopy studies indicated that the liquid vehicle tends to reduce the surface roughness of the pellet. X-ray powder diffraction (XRPD) indicated no significant differences in the crystalline structure or amorphous content between the physical mixture and the liqui-pellet formulation. This was due to the presence of a high concentration of amorphous Avicel in the formulation which overshadowed the crystalline structure of naproxen in the physical mixtures. Flowability and dissolution tests confirmed that this next-generation oral dosage form has excellent flowability, whilst maintaining the typical liquisolid enhanced drug release performance in comparison to its physical mixture counterpart. The liqui-pellet also had a high liquid load factor of 1, where ~ 29% of the total mass was the liquid vehicle. This shows that a high liquid load factor can be achieved in a liqui-pellet without compromising flowability. Overall, the results showed that the poor flowability of a liquisolid formulation could be overcomed with the liqui-pellet, which is believed to be a major advancement into the commercial feasibility of the liquisolid concept.Citation
Lam M, Ghafourian T, Nokhodchi A (2019) 'Liqui-pellet: the emerging next-generation oral dosage form which stems from liquisolid concept in combination with pelletization technology', AAPS PharmSciTech, 20 (6), pp.231-.Publisher
Springer New York LLCJournal
AAPS PharmSciTechPubMed ID
31236781PubMed Central ID
PMC6591193Additional Links
https://link.springer.com/article/10.1208/s12249-019-1441-9Type
ArticleLanguage
enEISSN
1530-9932ae974a485f413a2113503eed53cd6c53
10.1208/s12249-019-1441-9
Scopus Count
Collections
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International
Related articles
- Optimising the release rate of naproxen liqui-pellet: a new technology for emerging novel oral dosage form.
- Authors: Lam M, Ghafourian T, Nokhodchi A
- Issue date: 2020 Feb
- Factors affecting performance and manufacturability of naproxen Liqui-Pellet.
- Authors: Lam M, Nokhodchi A
- Issue date: 2020 Dec
- Liquisolid Pellets and Liqui-Pellets Are Not Different.
- Authors: Pezzini BR, Beringhs AO, Ferraz HG, Silva MAS, Stulzer HK, Sonaglio D
- Issue date: 2020 Jan 17
- Liqui-Tablet: the Innovative Oral Dosage Form Using the Newly Developed Liqui-Mass Technology.
- Authors: Lam M, Asare-Addo K, Nokhodchi A
- Issue date: 2021 Mar 1
- Liquisolid Technology: A State-of-the-Art Review on the Current State, Challenges, New and Emerging Technologies for Next Generation.
- Authors: Agiba AM
- Issue date: 2020