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dc.contributor.authorLiu, Yang
dc.contributor.authorWang, Zuobin
dc.contributor.authorWang, Xinyue
dc.contributor.illustrator
dc.date.accessioned2021-02-01T11:55:48Z
dc.date.available2021-02-01T11:55:48Z
dc.date.issued2014-12-18
dc.identifier.citationLiu Y, Wang Z, Wang X (2015) 'AFM-based study of fullerenol (C60(OH)24)-induced changes of elasticity in living SMCC-7721 cells', Journal of the Mechanical Behavior of Biomedical Materials, 45, pp.65-74.en_US
dc.identifier.issn1751-6161
dc.identifier.pmid25682196
dc.identifier.doi10.1016/j.jmbbm.2014.12.011
dc.identifier.urihttp://hdl.handle.net/10547/624797
dc.description.abstractIn this study, the alterations of the morphology and biomechanical properties of living SMCC-7721 cancer cells treated with fullerenol (C60(OH)24) for 24, 48, and 72h were investigated using an atomic force microscope (AFM). Comparative analyses show that the elastic moduli of the SMCC-7721 cells exposed to fullerenol decrease significantly with the increase of the treatment periods. Furthermore, in different phases of the treatment, a global decrease in elasticity is accompanied by cellular morphological changes, and the time-dependent effect of the fullerenol can be observed using AFM and optical microscope. In addition, as the treatment duration increases, the indentation force and depth penetrated into the cell membrane by the AFM tip are in a declining trend. The reduction in the stiffness of the cells exposed to fullerenol could be associated with the disruption of the cellular cytoskeleton network. The investigation indicates that the elastic modulus of single living cells can be a useful biomarker to evaluate the effects of fullerenol or other anticancer agents on the cells and reveal instructive information for cellular dynamic behaviors.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S1751616114003907en_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.subjectelastic modulusen_US
dc.subjectFullerenolen_US
dc.subjectAtomic force microscope (AFM)en_US
dc.subjectSMCC-7721 cellen_US
dc.subjectmorphologyen_US
dc.subjectnanoindentationen_US
dc.titleAFM-based study of fullerenol (C60(OH)24)-induced changes of elasticity in living SMCC-7721 cellsen_US
dc.typeArticleen_US
dc.contributor.departmentChangchun University of Science and Technologyen_US
dc.identifier.journalJournal of the Mechanical Behavior of Biomedical Materialsen_US
dc.date.updated2021-02-01T11:51:52Z
dc.description.note
refterms.dateFOA2021-02-01T11:59:13Z


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