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    AFM-based study of fullerenol (C60(OH)24)-induced changes of elasticity in living SMCC-7721 cells

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    Authors
    Liu, Yang
    Wang, Zuobin
    Wang, Xinyue
    Affiliation
    Changchun University of Science and Technology
    Issue Date
    2014-12-18
    Subjects
    elastic modulus
    Fullerenol
    Atomic force microscope (AFM)
    SMCC-7721 cell
    morphology
    nanoindentation
    
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    Abstract
    In this study, the alterations of the morphology and biomechanical properties of living SMCC-7721 cancer cells treated with fullerenol (C60(OH)24) for 24, 48, and 72h were investigated using an atomic force microscope (AFM). Comparative analyses show that the elastic moduli of the SMCC-7721 cells exposed to fullerenol decrease significantly with the increase of the treatment periods. Furthermore, in different phases of the treatment, a global decrease in elasticity is accompanied by cellular morphological changes, and the time-dependent effect of the fullerenol can be observed using AFM and optical microscope. In addition, as the treatment duration increases, the indentation force and depth penetrated into the cell membrane by the AFM tip are in a declining trend. The reduction in the stiffness of the cells exposed to fullerenol could be associated with the disruption of the cellular cytoskeleton network. The investigation indicates that the elastic modulus of single living cells can be a useful biomarker to evaluate the effects of fullerenol or other anticancer agents on the cells and reveal instructive information for cellular dynamic behaviors.
    Citation
    Liu Y, Wang Z, Wang X (2015) 'AFM-based study of fullerenol (C60(OH)24)-induced changes of elasticity in living SMCC-7721 cells', Journal of the Mechanical Behavior of Biomedical Materials, 45, pp.65-74.
    Publisher
    Elsevier
    Journal
    Journal of the Mechanical Behavior of Biomedical Materials
    URI
    http://hdl.handle.net/10547/624797
    DOI
    10.1016/j.jmbbm.2014.12.011
    PubMed ID
    25682196
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S1751616114003907
    Type
    Article
    Language
    en
    ISSN
    1751-6161
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jmbbm.2014.12.011
    Scopus Count
    Collections
    Computing

    entitlement

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