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dc.contributor.authorGao, Mingyan
dc.contributor.authorHuang, Yuxi
dc.contributor.authorHu, Cuihua
dc.contributor.authorHu, Jing
dc.contributor.authorWang, Ying
dc.contributor.authorChen, Yujuan
dc.contributor.authorSong, Guicai
dc.contributor.authorSong, Zhengxun
dc.contributor.authorWang, Zuobin
dc.date.accessioned2021-01-22T10:20:12Z
dc.date.available2022-12-02T00:00:00Z
dc.date.available2021-01-22T10:20:12Z
dc.date.issued2020-12-02
dc.identifier.citationGao M, Huang Y, Hu C, Hu J, Wang Y, Chen Y, Huang Y, Song G, Song Z, Wang Z (2020) 'Selective anticancer effect of Phellinus linteus on epidermoid cell lines studied by atomic force microscopy: anticancer activity on A431 cancer cells and low toxicity on HaCat normal cells', IEEE Nanotechnology Magazine, 15 (1), pp.4-16.en_US
dc.identifier.issn1932-4510
dc.identifier.doi10.1109/MNANO.2020.3037439
dc.identifier.urihttp://hdl.handle.net/10547/624779
dc.description.abstractThe research on the morphological and mechanical properties of single cells has provided a crucial way of understanding the cellular physiology and metabolism. In this study, the selective anticancer effects of Phellinus linteus on A431 and HaCat cells and their morphological and mechanical properties were systematically investigated by atomic force microscopy (AFM). Notably, the cell morphology on the micronano scale was observed under both the physiological environment and immobilization conditions. The significant morphological changes of A431 cells from the flat to spherical shape, the increase of cell height, and the decrease of the particles on the cell membrane were confirmed to be related to the cell apoptosis under the treatment of the Phellinus linteus water extract (PLWE). Moreover, the small morphology variations of HaCat cells showed that the PLWE presented a high anticancer effect on A431 cells but low toxicity on HaCat cells, which indicated a potential cell selectivity between cancer and normal cells. This work proved that Phellinus linteus could be used as a potential candidate for selective anticancer treatments.en_US
dc.language.isoenen_US
dc.publisherInstitute of Electrical and Electronics Engineers Inc.en_US
dc.relation.urlhttps://ieeexplore.ieee.org/document/9277888en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectcancer cellsen_US
dc.subjectatomic force microscopyen_US
dc.subjectSubject Categories::C710 Applied Molecular Biology, Biophysics and Biochemistryen_US
dc.titleSelective anticancer effect of Phellinus linteus on epidermoid cell lines studied by atomic force microscopy: anticancer activity on A431 cancer cells and low toxicity on HaCat normal cellsen_US
dc.typeArticleen_US
dc.identifier.eissn1942-7808
dc.contributor.departmentMinistry of Education Key Laboratory for Cross-Scale Micro and Nano Manufacturingen_US
dc.contributor.departmentJilin Universityen_US
dc.contributor.departmentChangchun University of Science and Technologyen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journalIEEE Nanotechnology Magazineen_US
dc.date.updated2021-01-22T10:14:13Z
dc.description.notehttps://v2.sherpa.ac.uk/id/publication/23044 24m embargo


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