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dc.contributor.authorWu, Xiaomin
dc.contributor.authorLi, Li
dc.contributor.authorLei, Zecheng
dc.contributor.authorYang, Fan
dc.contributor.authorLiu, Ri
dc.contributor.authorWang, Lu
dc.contributor.authorZhu, Xinyao
dc.contributor.authorWang, Zuobin
dc.date.accessioned2021-01-22T10:03:58Z
dc.date.available2020-11-17T00:00:00Z
dc.date.available2021-01-22T10:03:58Z
dc.date.issued2020-11-17
dc.identifier.citationWu X, Li L, Lei Z, Yang F, Liu R, Wang L, Zhu X, Wang Z (2020) 'Durotaxis behavior of bEnd.3 cells on soft substrate with patterned platinum nanoparticle array', Applied Nanoscience, 11, pp.611-620 .en_US
dc.identifier.issn2190-5509
dc.identifier.doi10.1007/s13204-020-01618-1
dc.identifier.urihttp://hdl.handle.net/10547/624778
dc.description.abstractThe directional arrangement of cells has crucial effect in tissue engineering fields such as wound healing and scar repair. Studies have shown that continuous nanostructures have directional regulatory effect on cells, but whether discontinuous nanostructures have the same regulatory effect on cells is also worthy of further study. Here, a series of discontinuous platinum nanoparticles (PtNPs) patterned on the surface of PDMS (PtNPs-PDMS&Glass) and glass (PtNPs-Glass) substrates were developed to investigate the effect on bEnd.3 cell durotaxis. The laser interference lithography and nanotransfer printing method were employed to fabricate the substrates. It was found that about 80% cells orderly arranged on the PtNPs-PDMS&Glass substrate, but only 20% cells orderly arrangement on the PtNPs-Glass substrate, and the number of cells on the PtNPs-PDMS&Glass substrate was five times more than that on the PDMS coated glass substrate (PDMS&Glass). The results suggested that patterning PtNPs on the PDMS substrate not only provided the topographical guidance for cells just like continuous nanostructures, but also promoted cell adhesion and growth. In addition, an improved whole cell coupling model was used to investigate and explain the cell durotaxis from the perspective of mechanism. These findings show the possibility of discontinuous nanostructures in regulating cell arrangement, and offer a useful method for the design of biological functional substrate, as well as help to understand the mechanism of cell durotaxis.en_US
dc.language.isoenen_US
dc.publisherSpringer Science and Business Mediaen_US
dc.relation.urlhttps://link.springer.com/article/10.1007/s13204-020-01618-1en_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPtNPsen_US
dc.subjectcell durotaxisen_US
dc.subjectcell coupling modelen_US
dc.subjectnanotransfer printing methodsen_US
dc.subjectSubject Categories::J510 Materials Technologyen_US
dc.titleDurotaxis behavior of bEnd.3 cells on soft substrate with patterned platinum nanoparticle arrayen_US
dc.typeArticleen_US
dc.identifier.eissn2190-5517
dc.contributor.departmentChangchun University of Science and Technologyen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.contributor.departmentTianjin Universityen_US
dc.identifier.journalApplied Nanoscienceen_US
dc.date.updated2021-01-22T09:57:55Z
dc.description.note1y embargo


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