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dc.contributor.authorAlenaini, Wareed
dc.contributor.authorParkinson, James R.
dc.contributor.authorMcCarthy, John
dc.contributor.authorGoldstone, Anthony P.
dc.contributor.authorWilman, Henry R.
dc.contributor.authorBanerjee, Rajarshi
dc.contributor.authorYaghootkar, Hanieh
dc.contributor.authorBell, Jimmy D.
dc.contributor.authorThomas, E. Louise
dc.date.accessioned2021-01-08T13:09:34Z
dc.date.available2021-01-08T13:09:34Z
dc.date.issued2020-09-16
dc.identifier.citationAlenaini W, Parkinson JRC, McCarthy JP, Goldstone AP, Wilman HR, Banerjee R, Yaghootkar H, Bell JD, Thomas EL (2020) 'Ethnic differences in body fat deposition and liver fat content in two UK-based cohorts', Obesity, 28 (11), pp.2142-2152.en_US
dc.identifier.issn1930-7381
dc.identifier.pmid32939982
dc.identifier.doi10.1002/oby.22948
dc.identifier.urihttp://hdl.handle.net/10547/624742
dc.description.abstractObjective: Differences in the content and distribution of body fat and ectopic lipids may be responsible for ethnic variations in metabolic disease susceptibility. The aim of this study was to examine the ethnic distribution of body fat in two separate UK-based populations. Methods: Anthropometry and body composition were assessed in two separate UK cohorts: the Hammersmith cohort and the UK Biobank, both comprising individuals of South Asian descent (SA), individuals of Afro-Caribbean descent (AC), and individuals of European descent (EUR). Regional adipose tissue stores and liver fat were measured by magnetic resonance techniques. Results: The Hammersmith cohort (n = 747) had a mean (SD) age of 41.1 (14.5) years (EUR: 374 men, 240 women; SA: 68 men, 22 women; AC: 14 men, 29 women), and the UK Biobank (n = 9,533) had a mean (SD) age of 55.5 (7.5) years (EUR: 4,483 men, 4,873 women; SA: 80 men, 43 women, AC: 31 men, 25 women). Following adjustment for age and BMI, no significant differences in visceral adipose tissue or liver fat were observed between SA and EUR individuals in the either cohort. Conclusions: Our data, consistent across two independent UK-based cohorts, present a limited number of ethnic differences in the distribution of body fat depots associated with metabolic disease. These results suggest that the ethnic variation in susceptibility to features of the metabolic syndrome may not arise from differences in body fat.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1002/oby.22948en_US
dc.rightsYellow - can archive pre-print (ie pre-refereeing)*
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectbody fat depositionen_US
dc.subjectliver faten_US
dc.subjectSubject Categories::B120 Physiologyen_US
dc.titleEthnic differences in body fat deposition and liver fat content in two UK-based cohortsen_US
dc.typeArticleen_US
dc.contributor.departmentUniversity of Westminsteren_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.contributor.departmentImperial College Londonen_US
dc.contributor.departmentPerspectum Diagnosticsen_US
dc.contributor.departmentUniversity of Exeteren_US
dc.contributor.departmentLuleå University of Technologyen_US
dc.identifier.journalObesityen_US
dc.date.updated2021-01-08T12:58:34Z
dc.description.note
refterms.dateFOA2021-01-08T13:09:35Z


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