Bovine milk fat globule epidermal growth factor Ⅷ activates PI3K/Akt signaling pathway and attenuates sarcopenia in rat model induced by D-galactose
dc.contributor.author | Li, He | |
dc.contributor.author | Wang, Rongchun | |
dc.contributor.author | Wang, Lifeng | |
dc.contributor.author | Li, Lin | |
dc.contributor.author | Ma, Ying | |
dc.contributor.author | Zhou, Shaobo | |
dc.date.accessioned | 2020-12-18T09:24:59Z | |
dc.date.available | 2021-12-17T00:00:00Z | |
dc.date.available | 2020-12-18T09:24:59Z | |
dc.date.issued | 2020-12-17 | |
dc.identifier.citation | Li H, Wang R, Wang LF, Li L, Ma Y, Zhou S (2020) 'Bovine milk fat globule epidermal growth factor Ⅷ activates PI3K/Akt signaling pathway and attenuates sarcopenia in rat model induced by D-galactose', Food Bioscience, 40 (100847) | en_US |
dc.identifier.issn | 2212-4292 | |
dc.identifier.doi | 10.1016/j.fbio.2020.100847 | |
dc.identifier.uri | http://hdl.handle.net/10547/624717 | |
dc.description.abstract | To develop a more effective and safer treatment for sarcopenia, this research investigated the anti-sarcopenia mechanism of Milk Fat Globule Epidermal Growth Factor Ⅷ (MFG-E8) from the liver function and metabolism in sarcopenic model rat. After 4 weeks nutritional intervention experiment, MFG-E8 can significantly increase the gastrocnemius mass in rat. The mechanism of MFG-E8 in improving sarcopenia was related to its promotional capacity to the activities of superoxide dismutase (SOD) activity in serum, Glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) in liver. Meanwhile, MFG-E8 could also down-regulate obesity-related indicators, such as triglyceride (TG) and Non-esterified fatty acid (NEFA). The analysis of liver and gastrocnemius histopathology found that MFG-E8 could reduce the accumulation of fatty vesicles, improve liver function, thereby alleviating gastrocnemius tissue inflammation. In vitro experiments, myoblasts obtained from gastrocnemius tissue showed that MFG-E8 could reduce mitochondrial autophagy and inhibit cell apoptosis. In addition, MFG-E8 could up-regulate the phosphorylation level of PI3K via activating PI3K/Akt signaling pathway in gastrocnemius tissue, and promote the formation of muscle fibers, thereby increasing muscle mass. Moreover, MFG-E8 could also promote the formation of neuromuscular junctions by up-regulating the mRNA and protein expression of MusK in gastrocnemius. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.url | https://www.sciencedirect.com/science/article/pii/S2212429220311858 | en_US |
dc.rights | ||
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | MFG-E8 | en_US |
dc.subject | sarcopenic model rat | en_US |
dc.subject | myoblasts | en_US |
dc.subject | PI3K/Akt signalling pathway | en_US |
dc.subject | Subject Categories::C910 Applied Biological Sciences | en_US |
dc.title | Bovine milk fat globule epidermal growth factor Ⅷ activates PI3K/Akt signaling pathway and attenuates sarcopenia in rat model induced by D-galactose | en_US |
dc.type | Article | en_US |
dc.contributor.department | Jiangsu Normal University | en_US |
dc.contributor.department | Harbin Institute of Technology | en_US |
dc.contributor.department | Northeast Agriculture University | en_US |
dc.contributor.department | University of Bedfordshire | en_US |
dc.identifier.journal | Food Bioscience | en_US |
dc.date.updated | 2020-12-18T09:13:11Z | |
dc.description.note | 12m embargo |