Show simple item record

dc.contributor.authorLi, He
dc.contributor.authorWang, Rongchun
dc.contributor.authorWang, Lifeng
dc.contributor.authorLi, Lin
dc.contributor.authorMa, Ying
dc.contributor.authorZhou, Shaobo
dc.date.accessioned2020-12-18T09:24:59Z
dc.date.available2021-12-17T00:00:00Z
dc.date.available2020-12-18T09:24:59Z
dc.date.issued2020-12-17
dc.identifier.citationLi H, Wang R, Wang LF, Li L, Ma Y, Zhou S (2020) 'Bovine milk fat globule epidermal growth factor Ⅷ activates PI3K/Akt signaling pathway and attenuates sarcopenia in rat model induced by D-galactose', Food Bioscience, 40 (100847)en_US
dc.identifier.issn2212-4292
dc.identifier.doi10.1016/j.fbio.2020.100847
dc.identifier.urihttp://hdl.handle.net/10547/624717
dc.description.abstractTo develop a more effective and safer treatment for sarcopenia, this research investigated the anti-sarcopenia mechanism of Milk Fat Globule Epidermal Growth Factor Ⅷ (MFG-E8) from the liver function and metabolism in sarcopenic model rat. After 4 weeks nutritional intervention experiment, MFG-E8 can significantly increase the gastrocnemius mass in rat. The mechanism of MFG-E8 in improving sarcopenia was related to its promotional capacity to the activities of superoxide dismutase (SOD) activity in serum, Glutamic-oxaloacetic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) in liver. Meanwhile, MFG-E8 could also down-regulate obesity-related indicators, such as triglyceride (TG) and Non-esterified fatty acid (NEFA). The analysis of liver and gastrocnemius histopathology found that MFG-E8 could reduce the accumulation of fatty vesicles, improve liver function, thereby alleviating gastrocnemius tissue inflammation. In vitro experiments, myoblasts obtained from gastrocnemius tissue showed that MFG-E8 could reduce mitochondrial autophagy and inhibit cell apoptosis. In addition, MFG-E8 could up-regulate the phosphorylation level of PI3K via activating PI3K/Akt signaling pathway in gastrocnemius tissue, and promote the formation of muscle fibers, thereby increasing muscle mass. Moreover, MFG-E8 could also promote the formation of neuromuscular junctions by up-regulating the mRNA and protein expression of MusK in gastrocnemius.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S2212429220311858en_US
dc.rights
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMFG-E8en_US
dc.subjectsarcopenic model raten_US
dc.subjectmyoblastsen_US
dc.subjectPI3K/Akt signalling pathwayen_US
dc.subjectSubject Categories::C910 Applied Biological Sciencesen_US
dc.titleBovine milk fat globule epidermal growth factor Ⅷ activates PI3K/Akt signaling pathway and attenuates sarcopenia in rat model induced by D-galactoseen_US
dc.typeArticleen_US
dc.contributor.departmentJiangsu Normal Universityen_US
dc.contributor.departmentHarbin Institute of Technologyen_US
dc.contributor.departmentNortheast Agriculture Universityen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journalFood Bioscienceen_US
dc.date.updated2020-12-18T09:13:11Z
dc.description.note12m embargo


Files in this item

Thumbnail
Name:
Publisher version
Thumbnail
Name:
Bovine+Milk+Fat+Globule+Epider ...
Size:
2.074Mb
Format:
PDF
Description:
author's accepted version

This item appears in the following Collection(s)

Show simple item record

Except where otherwise noted, this item's license is described as