Cleavage of mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis

Authors
Law, Ah-Lai
Parinot, Celia
Chatagnon, Jonathan
Gravez, Basile
Sahel, Jose-Alain
Bhattacharya, Shomi S.
Nandrot, Emeline F.
Affiliation
Sorbonne Universite
University College London
Andalusian Center of Molecular Biology and Regenerative Medicine
Issue Date
2014-12-23
Subjects
phagocytosis
Subject Categories::C131 Applied Cell Biology

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Abstract
Background: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.
Citation
Law AL, Parinot C, Chatagnon J, Gravez B, Sahel JA, Bhattacharya SS, Nandrot EF (2015) 'Cleavage of mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis', Journal of Biological Chemistry, 290 (8), pp.4941-4952.
Publisher
American Society for Biochemistry and Molecular Biology Inc.
Journal
Journal of Biological Chemistry
URI
http://hdl.handle.net/10547/624685
DOI
10.1074/jbc.M114.628297
PubMed ID
25538233
PubMed Central ID
PMC4335232
Additional Links
https://www.jbc.org/content/290/8/4941.long
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335232/
Type
Article
Language
en
ISSN
0021-9258
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