Cleavage of mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis
Authors
Law, Ah-LaiParinot, Celia
Chatagnon, Jonathan
Gravez, Basile
Sahel, Jose-Alain
Bhattacharya, Shomi S.
Nandrot, Emeline F.
Affiliation
Sorbonne UniversiteUniversity College London
Andalusian Center of Molecular Biology and Regenerative Medicine
Issue Date
2014-12-23
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Show full item recordAbstract
Background: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.Citation
Law AL, Parinot C, Chatagnon J, Gravez B, Sahel JA, Bhattacharya SS, Nandrot EF (2015) 'Cleavage of mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis', Journal of Biological Chemistry, 290 (8), pp.4941-4952.Journal
Journal of Biological ChemistryPubMed ID
25538233PubMed Central ID
PMC4335232Additional Links
https://www.jbc.org/content/290/8/4941.longhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335232/
Type
ArticleLanguage
enISSN
0021-9258ae974a485f413a2113503eed53cd6c53
10.1074/jbc.M114.628297
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