Cleavage of mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis
Bhattacharya, Shomi S.
Nandrot, Emeline F.
University College London
Andalusian Center of Molecular Biology and Regenerative Medicine
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AbstractBackground: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.
CitationLaw AL, Parinot C, Chatagnon J, Gravez B, Sahel JA, Bhattacharya SS, Nandrot EF (2015) 'Cleavage of mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis', Journal of Biological Chemistry, 290 (8), pp.4941-4952.
JournalJournal of Biological Chemistry
PubMed Central IDPMC4335232
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