• Login
    View Item 
    •   Home
    • Research from April 2016
    • Biomedical and biological science
    • View Item
    •   Home
    • Research from April 2016
    • Biomedical and biological science
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UOBREPCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalDepartmentThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalDepartment

    My Account

    LoginRegister

    About

    AboutLearning ResourcesResearch Graduate SchoolResearch InstitutesUniversity Website

    Statistics

    Display statistics

    Cleavage of mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Law, Ah-Lai
    Parinot, Celia
    Chatagnon, Jonathan
    Gravez, Basile
    Sahel, Jose-Alain
    Bhattacharya, Shomi S.
    Nandrot, Emeline F.
    Affiliation
    Sorbonne Universite
    University College London
    Andalusian Center of Molecular Biology and Regenerative Medicine
    Issue Date
    2014-12-23
    Subjects
    phagocytosis
    Subject Categories::C131 Applied Cell Biology
    
    Metadata
    Show full item record
    Abstract
    Background: The MerTK receptor is necessary for retinal phagocytosis and its daily rhythm. Results: MerTK is cleaved from the apical cell surface in vitro and in vivo, reducing the phagocytic capacity of RPE cells. Conclusion: MerTK cleavage might help control the duration of the daily phagocytic peak. Significance: Our data show that extracellular cleavage of MerTK partly regulates retinal phagocytosis.
    Citation
    Law AL, Parinot C, Chatagnon J, Gravez B, Sahel JA, Bhattacharya SS, Nandrot EF (2015) 'Cleavage of mer tyrosine kinase (MerTK) from the cell surface contributes to the regulation of retinal phagocytosis', Journal of Biological Chemistry, 290 (8), pp.4941-4952.
    Publisher
    American Society for Biochemistry and Molecular Biology Inc.
    Journal
    Journal of Biological Chemistry
    URI
    http://hdl.handle.net/10547/624685
    DOI
    10.1074/jbc.M114.628297
    PubMed ID
    25538233
    PubMed Central ID
    PMC4335232
    Additional Links
    https://www.jbc.org/content/290/8/4941.long
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335232/
    Type
    Article
    Language
    en
    ISSN
    0021-9258
    ae974a485f413a2113503eed53cd6c53
    10.1074/jbc.M114.628297
    Scopus Count
    Collections
    Biomedical and biological science

    entitlement

    Related articles

    • Retinal pigment epithelial cells use a MerTK-dependent mechanism to limit the phagocytic particle binding activity of αvβ5 integrin.
    • Authors: Nandrot EF, Silva KE, Scelfo C, Finnemann SC
    • Issue date: 2012 Jun
    • Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.
    • Authors: Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC
    • Issue date: 2007 Jul 17
    • Essential diurnal Rac1 activation during retinal phagocytosis requires αvβ5 integrin but not tyrosine kinases focal adhesion kinase or Mer tyrosine kinase.
    • Authors: Mao Y, Finnemann SC
    • Issue date: 2012 Mar
    • Mertk in daily retinal phagocytosis: a history in the making.
    • Authors: Nandrot EF, Dufour EM
    • Issue date: 2010
    • MERTK interactions with SH2-domain proteins in the retinal pigment epithelium.
    • Authors: Shelby SJ, Colwill K, Dhe-Paganon S, Pawson T, Thompson DA
    • Issue date: 2013
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.