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    Gut hormone regulation and secretion via FFA1 and FFA4

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    Authors
    Gribble, Fiona M.
    Diakogiannaki, Eleftheria
    Reimann, Frank
    Issue Date
    2016-11-22
    Subjects
    CCK
    Incretin
    FFA1
    Ghrelin
    FFA4
    GIP
    GLP-1
    
    Metadata
    Show full item record
    Other Titles
    Free Fatty Acid Receptors
    Abstract
    The digestion, absorption and utilisation of dietary triglycerides are controlled by gut hormones, released from enteroendocrine cells along the length of the gastrointestinal tract. Major players in the detection of ingested lipids are the free fatty acid receptors FFA1 and FFA4, which are highly expressed on enteroendocrine cells. These receptors are activated when free fatty acids (FFA) are absorbed across the intestinal epithelium, and provide a dynamic hormonal signal indicating that lipids are arriving in the bloodstream from the gut. This review addresses our current knowledge of how ingested triglycerides modulate gut hormone release via FFA1 and FFA4.
    Citation
    Gribble F, Diakogiannaki E, Reimann F (2017) 'Gut hormone regulation and secretion via FFA1 and FFA4', in Free Fatty Acid Receptors , Springer New York LLC
    Publisher
    Springer New York LLC
    URI
    http://hdl.handle.net/10547/624681
    DOI
    10.1007/164_2016_46
    PubMed ID
    27873089
    Additional Links
    https://link.springer.com/chapter/10.1007%2F164_2016_46
    Type
    Book chapter
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1007/164_2016_46
    Scopus Count
    Collections
    Biomedical and biological science

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