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dc.contributor.authorJones, Arwel
dc.contributor.authorMarch, Daniel S.
dc.contributor.authorCurtis, Ffion
dc.contributor.authorBridle, Christopher
dc.date.accessioned2020-11-23T10:06:10Z
dc.date.available2016-07-26T00:00:00Z
dc.date.available2020-11-23T10:06:10Z
dc.date.issued2016-07-26
dc.identifier.citationJones A, March D, Curtis F, Bridle C (2016) 'Bovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trials', BMC Sports Science, Medicine and Rehabilitation, 8 (1)en_US
dc.identifier.doi10.1186/s13102-016-0047-8
dc.identifier.urihttp://hdl.handle.net/10547/624630
dc.description.abstractBackground: Bovine colostrum is proposed as a nutritional countermeasure to the risk of upper respiratory symptoms (URS) during exercise training. The aim of this systematic review and meta-analysis was to estimate the size of the effect of bovine colostrum supplementation on URS. Methods: Databases (CDSR, CENTRAL, Cinahl, ClinicalTrials.gov, Current Controlled Trials, DARE, EMBASE, Medline, PROSPERO and Web of Science) of published, unpublished and ongoing studies were searched for randomised controlled trials of healthy adults (≥18 years), evaluating the effect of oral bovine colostrum supplementation compared to a concurrent control group on URS. Results: Five trials (152 participants) met the inclusion criteria, all of which involved individuals involved in regular exercise training. Over an 8-12 week follow-up period, bovine colostrum supplementation when compared to placebo significantly reduced the incidence rate of URS days (rate ratio 0.56, 95 % confidence intervals 0.43 to 0.72, P value < 0.001) and URS episodes (0.62, 0.40 to 0.99, P value = 0.04) by 44 and 38 % respectively. There were limited data and considerable variation in results of included studies for duration of URS episodes hence a meta-analysis of this outcome was deemed inappropriate. The risk of bias assessment in this review was hindered by poor reporting practices of included studies. Due to incomplete reporting of study methods, four of the five studies were judged to have a moderate or high risk of overall bias. Our findings must be interpreted in relation to quantity and quality of the available evidence. Conclusions: The present systematic review and meta-analysis provides evidence that bovine colostrum supplementation may be effective in preventing the incidence of URS days and episodes in adults engaged in exercise training. The fact that the majority of included studies did not report significant effects on URS outcomes mitigates concerns about publication bias. The point estimates of the random-effects meta-analyses are greater than the smallest clinically important difference, but the low precision of the individual study estimates means the evidence presented in this review needs to be followed up with an appropriately designed and adequately powered, randomised control trial.en_US
dc.language.isoenen_US
dc.publisherBioMed Central Ltd.en_US
dc.relation.urlhttps://bmcsportsscimedrehabil.biomedcentral.com/articles/10.1186/s13102-016-0047-8en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectathletesen_US
dc.subjectexercise trainingen_US
dc.subjectfirst milken_US
dc.subjectURTIen_US
dc.subjectBovine colostrumen_US
dc.subjectrespiratory illnessen_US
dc.subjectSubject Categories::C600 Sports Scienceen_US
dc.titleBovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trialsen_US
dc.typeArticleen_US
dc.identifier.eissn2052-1847
dc.identifier.journalBMC Sports Science, Medicine and Rehabilitationen_US
dc.date.updated2020-11-23T10:03:01Z
dc.description.noteopen access with cc licence


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