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dc.contributor.authorYoung, Hannah M.L.
dc.contributor.authorMarch, Daniel S.
dc.contributor.authorGraham-Brown, Matthew P.M .
dc.contributor.authorJones, Arwel
dc.contributor.authorCurtis, Ffion
dc.contributor.authorGrantham, Charlotte S.
dc.contributor.authorChurchward, Darren R.
dc.contributor.authorHighton, Patrick
dc.contributor.authorSmith, Alice C.
dc.contributor.authorSingh, Sally J.
dc.contributor.authorBridle, Christopher
dc.contributor.authorBurton, James O.
dc.contributor.illustrator
dc.date.accessioned2020-11-20T12:55:43Z
dc.date.available2020-11-20T00:00:00Z
dc.date.available2020-11-20T12:55:43Z
dc.date.issued2018-03-28
dc.identifier.citationYoung HML, March DS, Graham-Brown MPM, Jones AW, Curtis F, Grantham CS, Churchward DR, Highton P, Smith AC, Singh SJ, Bridle C, Burton JO (2018) 'Effects of intradialytic cycling exercise on exercise capacity, quality of life, physical function and cardiovascular measures in adult haemodialysis patients: a systematic review and meta-analysis', Nephrology Dialysis Transplantation, 33 (8), pp.1436-1445.en_US
dc.identifier.issn0931-0509
dc.identifier.pmid29608708
dc.identifier.doi10.1093/ndt/gfy045
dc.identifier.urihttp://hdl.handle.net/10547/624627
dc.description.abstractBackground. Intradialytic cycling (IDC), delivered during haemodialysis (HD), has the potential to improve many health issues. This systematic review and meta-analysis examine the evidence on the effects of IDC on exercise capacity, quality of life (QoL), physical function and cardiovascular health. Methods. Twenty-four databases were searched alongside Internet and hand searching, and consultation with experts. Eligibility criteria were cluster randomized, randomized and quasi-randomized controlled trials (RCTs) of IDC versus usual care in prevalent adult HD patients. Primary outcome measures were exercise capacity (VO2 peak and field tests) and QoL. Secondary measures were cardiac and physical function. Results. Thirteen RCTs were eligible. Eight provided data for use in meta-analyses, which indicated no significant change in VO2 peak (mean difference, MD 1.19 mL/kg/min, 95% confidence interval 1.15 to 3.52, P ¼ 0.3), physical (mean change, MC 1.97, 8.27 to 12.22, P ¼ 0.7) or mental component (MC 3.37, 7.94 to 14.68, P ¼ 0.6) summary scores of the Medical Outcomes Short Form 36, pulse wave velocity (MD 0.57 m/s, 1.55 to 0.41, P ¼ 0.4), systolic (MD 2.28 mmHg, 14.46 to 9.90, P ¼ 0.7) or diastolic blood pressure (MD 2.25 mmHg, 3.01 to 7.50, P ¼ 0.4) following IDC. IDC, however, leads to an improvement in performance on the 6-min walk test (MD 87.84 m, 39.60-136.09, P ¼ 0.0004). All included studies were considered to have high risk of bias. Conclusions. There is insufficient evidence demonstrating whether cycling exercise during HD improves patient outcomes. High-quality, adequately powered RCTs of IDC are required.en_US
dc.description.sponsorshipThe research was supported by the National Institute for Health Research (NIHR) Leicester Biomedical Research Centre. This research was part funded by the Stoneygate Trust. H.M.L.Y. and J.O.B. were supported by grants from the NIHR (Grant award number: DRF-2016-09-015 and CS- 2013-13-014). The views expressed in this publication are those of the author(s) and not necessarily those of the National Health Service, the NIHR or the Department of Health. The funders had no role in study design; collection, analysis and interpretation of data; writing the report; and the decision to submit the report for publication. SJS is supported by the Collaboration for Leadership in Applied Health Research and Care (CLAHRC) East Midlands.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.urlhttps://academic.oup.com/ndt/article/33/8/1436/4955890en_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjecthaemodialysisen_US
dc.subjectsystematic reviewsen_US
dc.subjectexerciseen_US
dc.subjectESRDen_US
dc.subjectmeta-analysisen_US
dc.subjectSubject Categories::C841 Health Psychologyen_US
dc.titleEffects of intradialytic cycling exercise on exercise capacity, quality of life, physical function and cardiovascular measures in adult haemodialysis patients: a systematic review and meta-analysisen_US
dc.typeArticleen_US
dc.identifier.journalNephrology Dialysis Transplantationen_US
dc.date.updated2020-11-20T12:44:46Z
dc.description.notefull text from https://leicester.figshare.com/articles/journal_contribution/Effects_of_intradialytic_cycling_exercise_on_exercise_capacity_quality_of_life_physical_function_and_cardiovascular_measures_in_adult_haemodialysis_patients_a_systematic_review_and_meta-analysis/10237760/files/18476408.pdf


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