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dc.contributor.authorKlaus, Kristel
dc.contributor.authorButler, Kevin
dc.contributor.authorCurtis, Ffion
dc.contributor.authorBridle, Christopher
dc.contributor.authorPennington, Kyla
dc.identifier.citationKlaus K, Butler K, Curtis F, Bridle C, Pennington K (2019) 'The effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: a systematic review and meta-analysis', Neuroscience and Biobehavioral Reviews, 100, pp.224-236.en_US
dc.description.abstractResearch in healthy adults suggests that C957T polymorphism of the dopamine D2 receptor encoding DRD2 and the Taq1A polymorphism of the neighbouring gene ankyrin repeat and kinase domain containing 1 (ANKK1) alter dopaminergic signalling and may influence prefrontally-mediated executive functions. A systematic review and meta-analysis was carried out on the evidence for the association of DRD2 C957T and ANKK1 Taq1A polymorphisms in performance on tasks relating to the three core domains of executive function: working memory, response inhibition and cognitive flexibility in healthy adults. CINAHL, MEDLINE, PsycARTICLES and PsychINFO databases were searched for predefined key search terms associated with the two polymorphisms and executive function. Studies were included if they investigated a healthy adult population with the mean age of 18–65 years, no psychiatric or neurological disorder and only the healthy adult arm were included in studies with any case-control design. Data from 17 independent studies were included in meta-analysis, separated by the Taq1A and C957T polymorphisms and by executive function tests: working memory (Taq1A, 6 samples, n = 1270; C957 T, 6 samples, n = 977), cognitive flexibility (C957 T, 3 samples, n = 620), and response inhibition (C957 T, 3 samples, n = 598). The meta-analyses did not establish significant associations between these gene polymorphisms of interest and any of the executive function domains. Theoretical implications and methodological considerations of these findings are discussed.en_US
dc.publisherElsevier Ltden_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.subjectworking memoryen_US
dc.subjectDRD2 C957Ten_US
dc.subjectcognitive flexibilityen_US
dc.subjectANKK1 Taq1Aen_US
dc.subjectexecutive functionen_US
dc.subjectresponse inhibitionen_US
dc.subjectSubject Categories::C810 Applied Psychologyen_US
dc.titleThe effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: a systematic review and meta-analysisen_US
dc.contributor.departmentUniversity of Lincolnen_US
dc.identifier.journalNeuroscience and Biobehavioral Reviewsen_US
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