The effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: a systematic review and meta-analysis
AffiliationUniversity of Lincoln
Subject Categories::C810 Applied Psychology
MetadataShow full item record
AbstractResearch in healthy adults suggests that C957T polymorphism of the dopamine D2 receptor encoding DRD2 and the Taq1A polymorphism of the neighbouring gene ankyrin repeat and kinase domain containing 1 (ANKK1) alter dopaminergic signalling and may influence prefrontally-mediated executive functions. A systematic review and meta-analysis was carried out on the evidence for the association of DRD2 C957T and ANKK1 Taq1A polymorphisms in performance on tasks relating to the three core domains of executive function: working memory, response inhibition and cognitive flexibility in healthy adults. CINAHL, MEDLINE, PsycARTICLES and PsychINFO databases were searched for predefined key search terms associated with the two polymorphisms and executive function. Studies were included if they investigated a healthy adult population with the mean age of 18–65 years, no psychiatric or neurological disorder and only the healthy adult arm were included in studies with any case-control design. Data from 17 independent studies were included in meta-analysis, separated by the Taq1A and C957T polymorphisms and by executive function tests: working memory (Taq1A, 6 samples, n = 1270; C957 T, 6 samples, n = 977), cognitive flexibility (C957 T, 3 samples, n = 620), and response inhibition (C957 T, 3 samples, n = 598). The meta-analyses did not establish significant associations between these gene polymorphisms of interest and any of the executive function domains. Theoretical implications and methodological considerations of these findings are discussed.
CitationKlaus K, Butler K, Curtis F, Bridle C, Pennington K (2019) 'The effect of ANKK1 Taq1A and DRD2 C957T polymorphisms on executive function: a systematic review and meta-analysis', Neuroscience and Biobehavioral Reviews, 100, pp.224-236.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Green - can archive pre-print and post-print or publisher's version/PDF
- Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers.
- Authors: Fagundo AB, Fernández-Aranda F, de la Torre R, Verdejo-García A, Granero R, Penelo E, Gené M, Barrot C, Sánchez C, Alvarez-Moya E, Ochoa C, Aymamí MN, Gómez-Peña M, Menchón JM, Jiménez-Murcia S
- Issue date: 2014 Dec
- The effect of <i>COMT Val158Met</i> and <i>DRD2 C957T</i> polymorphisms on executive function and the impact of early life stress.
- Authors: Klaus K, Butler K, Durrant SJ, Ali M, Inglehearn CF, Hodgson TL, Gutierrez H, Pennington K
- Issue date: 2017 May
- Posttraumatic Brain Injury Cognitive Performance Is Moderated by Variation Within ANKK1 and DRD2 Genes.
- Authors: Failla MD, Myrga JM, Ricker JH, Dixon CE, Conley YP, Wagner AK
- Issue date: 2015 Nov-Dec
- C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity.
- Authors: Hirvonen MM, Laakso A, Någren K, Rinne JO, Pohjalainen T, Hietala J
- Issue date: 2009 Oct
- An association study of <i>Taq1A ANKK1</i> and <i>C957T</i> and - <i>141C DRD2</i> polymorphisms in adults with internet gaming disorder: a pilot study.
- Authors: Paik SH, Choi MR, Kwak SM, Bang SH, Chun JW, Kim JY, Choi J, Cho H, Jeong JE, Kim DJ
- Issue date: 2017