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    Antitumor effects of saponin extract from Patrinia villosa (Thunb.) Juss on mice bearing U14 cervical cancer

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    Authors
    Zhang, Tao
    Li, Qingwang
    Li, Kun
    Li, Yurong
    Li, Jian
    Wang, Guijie
    Zhou, Shaobo
    Issue Date
    2008-04-29
    Subjects
    cervical cancer
    
    Metadata
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    Abstract
    Saponin extracted from Patrinia villosa (Thunb.) Juss (SPVJ) is a Chinese medicine which is used widely by traditional medicine doctors. In this study, the antitumor effects and the possible mechanisms of SPVJ were investigated in mice bearing U14 cervical cancer. The results showed that SPVJ (50 mg/kg and 100 mg/kg) effectively reduced the weight of U14 cervical tumor (35.1% and 57.1%, respectively). Compared with the control group, SPVJ (100 mg/kg) significantly increased tumor cells in the G0/G1 phase (38.1% vs 68.5%), increased the number of cells in apoptosis (9.4% vs 28.9%) and G0/G1 phase and decreased the number of cells in S phase (41% vs 26.2%) and G2/M (20.9% vs 5.3%), inhibited proliferating cell nuclear antigen (PCNA) of tumor cell (80.6% vs 21.8%), decreased the expression of mutant p53 (66.4% vs 33.5%) and bcl-2 protein (78.2% vs 20.3%). The mechanism of the SPVJ antitumor effect might be associated with inhibition of tumor cells in G0/G1 phase, inducing apoptosis and inhibiting the expression of PCNA, mutant P53 and Bcl-2 protein.
    Citation
    Zhang T, Li Q, Li K, Li Y, Li J, Wang G, Zhou S (2008) 'Antitumor effects of saponin extract from Patrinia villosa (Thunb.) Juss on mice bearing U14 cervical cancer', Phytotherapy Research, 22 (5), pp.640-645.
    Publisher
    Wiley
    Journal
    Phytotherapy Research
    URI
    http://hdl.handle.net/10547/624610
    DOI
    10.1002/ptr.2354
    PubMed ID
    18350512
    Additional Links
    https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.2354
    Type
    Article
    Language
    en
    ISSN
    0951-418X
    ae974a485f413a2113503eed53cd6c53
    10.1002/ptr.2354
    Scopus Count
    Collections
    Biomedical and biological science

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