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dc.contributor.authorShaher, Fahmi
dc.contributor.authorQiu, Hong-Bin
dc.contributor.authorWang, Shuqiu
dc.contributor.authorHu, Yu
dc.contributor.authorWang, Weiqun
dc.contributor.authorZhang, Yu
dc.contributor.authorWei, Yao
dc.contributor.authorAL-ward, Hisham
dc.contributor.authorAbdulghani, Mahfoudh A. M.
dc.contributor.authorAlenezi, Sattam Khulaif
dc.contributor.authorBaldi, Salem
dc.contributor.authorZhou, Shaobo
dc.date.accessioned2020-08-03T09:15:27Z
dc.date.available2020-07-25T00:00:00Z
dc.date.available2020-08-03T09:15:27Z
dc.date.issued2020-07-25
dc.identifier.citationShaher F, Qiu H, Wang S, Hu Y, Wang W, Zhang Y, Wei Y, AL-ward H, Abdulghani MAM, Alenezi SK, Baldi S, Zhou S (2020) 'Associated targets of the antioxidant cardioprotection of Ganoderma lucidum in diabetic cardiomyopathy by using open targets platform: a systematic review', BioMed Research International, 2020, pp.1-20.en_US
dc.identifier.issn2314-6133
dc.identifier.pmid32775437
dc.identifier.doi10.1155/2020/7136075
dc.identifier.urihttp://hdl.handle.net/10547/624303
dc.description.abstractEven with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. Methods. The OTP website version of 19.11 was accessed in December 2019 to identify the studies in DCM involving G. lucidum. Results. Among the 157 cell targets associated with DCM, the mammalian target of rapamycin (mTOR) was shared by all evidence, drug, and text mining data with 0.08 score association. mTOR also had the highest score association 0.1 with autophagy in DCM. Among the 1731 studies of indexed PubMed articles on G. lucidum published between 1985 and 2019, 33 addressed the antioxidant effects of G. lucidum and its molecular signal pathways involving oxidative stress and therefore were included in the current work. Conclusion. mTOR is one of the targets by DCM and can be inhibited by the antioxidative properties of G. lucidum directly via scavenging radicals and indirectly via modulating mTOR signal pathways such as Wnt signaling pathway, Erk1/2 signaling, and NF-κB pathways.en_US
dc.language.isoenen_US
dc.publisherHindawien_US
dc.relation.urlhttps://www.hindawi.com/journals/bmri/2020/7136075/en_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectdiabetic cardiomyopathyen_US
dc.subjectGanoderma lucidumen_US
dc.subjectSubject Categories::B810 Cardiographyen_US
dc.titleAssociated targets of the antioxidant cardioprotection of Ganoderma lucidum in diabetic cardiomyopathy by using open targets platform: a systematic reviewen_US
dc.title.alternativeCardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathyen_US
dc.typeArticleen_US
dc.contributor.departmentJiamusi Universityen_US
dc.contributor.departmentQassim Universityen_US
dc.contributor.departmentDalian Medical Universityen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journalBioMed Research Internationalen_US
dc.identifier.pmcidPMC7397440
dc.date.updated2020-08-03T09:08:39Z
dc.description.noteopen access


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