Associated targets of the antioxidant cardioprotection of Ganoderma lucidum in diabetic cardiomyopathy by using open targets platform: a systematic review
Authors
Shaher, FahmiQiu, Hong-Bin
Wang, Shuqiu
Hu, Yu
Wang, Weiqun
Zhang, Yu
Wei, Yao
AL-ward, Hisham
Abdulghani, Mahfoudh A. M.
Alenezi, Sattam Khulaif
Baldi, Salem
Zhou, Shaobo
Issue Date
2020-07-25
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Cardioprotection of Ganoderma lucidum in Diabetic CardiomyopathyAbstract
Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase. Hence, a feasible therapeutic approach is urgently needed. Objectives. This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G. lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website. Methods. The OTP website version of 19.11 was accessed in December 2019 to identify the studies in DCM involving G. lucidum. Results. Among the 157 cell targets associated with DCM, the mammalian target of rapamycin (mTOR) was shared by all evidence, drug, and text mining data with 0.08 score association. mTOR also had the highest score association 0.1 with autophagy in DCM. Among the 1731 studies of indexed PubMed articles on G. lucidum published between 1985 and 2019, 33 addressed the antioxidant effects of G. lucidum and its molecular signal pathways involving oxidative stress and therefore were included in the current work. Conclusion. mTOR is one of the targets by DCM and can be inhibited by the antioxidative properties of G. lucidum directly via scavenging radicals and indirectly via modulating mTOR signal pathways such as Wnt signaling pathway, Erk1/2 signaling, and NF-κB pathways.Citation
Shaher F, Qiu H, Wang S, Hu Y, Wang W, Zhang Y, Wei Y, AL-ward H, Abdulghani MAM, Alenezi SK, Baldi S, Zhou S (2020) 'Associated targets of the antioxidant cardioprotection of Ganoderma lucidum in diabetic cardiomyopathy by using open targets platform: a systematic review', BioMed Research International, 2020, pp.1-20.Publisher
HindawiJournal
BioMed Research InternationalPubMed ID
32775437PubMed Central ID
PMC7397440Additional Links
https://www.hindawi.com/journals/bmri/2020/7136075/Type
ArticleLanguage
enISSN
2314-6133ae974a485f413a2113503eed53cd6c53
10.1155/2020/7136075
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