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dc.contributor.authorXie, Chenchen
dc.contributor.authorDing, Ran
dc.contributor.authorWang, Xinyue
dc.contributor.authorYan, Jin
dc.contributor.authorWang, Ying
dc.contributor.authorZhang, Wenxiao
dc.contributor.authorQu, Yingmin
dc.contributor.authorWang, Zuobin
dc.date.accessioned2020-07-07T12:09:03Z
dc.date.available2020-07-07T12:09:03Z
dc.date.issued2020-01-02
dc.identifier.citationXie C, Ding R, Wang X, Yan J, Wang Y, Zhang W, Qu Y, Wang Z (2019) 'A disulfiram-loaded fibers scaffold fabricated via electrospinning method', 2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) - Zhenjiang, IEEE.en_US
dc.identifier.issn2373-5422
dc.identifier.doi10.1109/3M-NANO46308.2019.8947382
dc.identifier.urihttp://hdl.handle.net/10547/624158
dc.description.abstractIn this study, we developed a disulfiram-loaded fibers scaffold via the electrospinning method for enhancing the stability of disulfiram and facilitating the appropriate distribution in tumor tissues. The drug release profile of the disulfiram-loaded fibers scaffold was examined by high-performance liquid chromatography. The results showed that both the initial burst release and the subsequent sustainable release of the drug were suitable for cancer treatments. The results of an MTT assay, which tested the therapeutic efficacy of electrospun fibers in vitro, showed that the DSF-PVDF fibers exhibited their anticancer activity due to the incorporation of DSF. It indicates that DSF is successfully incorporated into the electrospun fibers and the resultant electrospun fibers are highly promising for cancer treatments.en_US
dc.language.isoenen_US
dc.publisherIEEEen_US
dc.relation.urlhttps://ieeexplore.ieee.org/document/8947382en_US
dc.subjectdisulfiramen_US
dc.subjectnanofibers scaffolden_US
dc.subjectelectrospinningen_US
dc.subjectcancer treatmenten_US
dc.titleA disulfiram-loaded fibers scaffold fabricated via electrospinning methoden_US
dc.typeConference papers, meetings and proceedingsen_US
dc.contributor.departmentChangchun University of Science and Technologyen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journal2017 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (3M-NANO)en_US
dc.date.updated2020-07-07T12:03:19Z
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