A disulfiram-loaded fibers scaffold fabricated via electrospinning method
Abstract
In this study, we developed a disulfiram-loaded fibers scaffold via the electrospinning method for enhancing the stability of disulfiram and facilitating the appropriate distribution in tumor tissues. The drug release profile of the disulfiram-loaded fibers scaffold was examined by high-performance liquid chromatography. The results showed that both the initial burst release and the subsequent sustainable release of the drug were suitable for cancer treatments. The results of an MTT assay, which tested the therapeutic efficacy of electrospun fibers in vitro, showed that the DSF-PVDF fibers exhibited their anticancer activity due to the incorporation of DSF. It indicates that DSF is successfully incorporated into the electrospun fibers and the resultant electrospun fibers are highly promising for cancer treatments.Citation
Xie C, Ding R, Wang X, Yan J, Wang Y, Zhang W, Qu Y, Wang Z (2019) 'A disulfiram-loaded fibers scaffold fabricated via electrospinning method', 2019 IEEE International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO) - Zhenjiang, IEEE.Publisher
IEEEAdditional Links
https://ieeexplore.ieee.org/document/8947382Type
Conference papers, meetings and proceedingsLanguage
enISSN
2373-5422ae974a485f413a2113503eed53cd6c53
10.1109/3M-NANO46308.2019.8947382