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dc.contributor.authorWang, Zihui
dc.contributor.authorLang, Baihe
dc.contributor.authorQu, Yingmin
dc.contributor.authorLi, Li
dc.contributor.authorSong, Zhengxun
dc.contributor.authorWang, Zuobin
dc.contributor.illustrator
dc.date.accessioned2020-06-29T09:20:04Z
dc.date.available2020-06-29T09:20:04Z
dc.date.issued2019-11-11
dc.identifier.citationWang Z, Lang B, Qu Y, Li L, Song Z, Wang Z (2019) 'Single-cell patterning technology for biological applications', Biomicrofluidics, 13 (6), pp.061502.en_US
dc.identifier.issn1932-1058
dc.identifier.pmid31737153
dc.identifier.doi10.1063/1.5123518
dc.identifier.urihttp://hdl.handle.net/10547/624112
dc.description.abstractSingle-cell patterning technology has revealed significant contributions of single cells to conduct basic and applied biological studies in vitro such as the understanding of basic cell functions, neuronal network formation, and drug screening. Unlike traditional population-based cell patterning approaches, single-cell patterning is an effective technology of fully understanding cell heterogeneity by precisely controlling the positions of individual cells. Therefore, much attention is currently being paid to this technology, leading to the development of various micro-nanofabrication methodologies that have been applied to locate cells at the single-cell level. In recent years, various methods have been continuously improved and innovated on the basis of existing ones, overcoming the deficiencies and promoting the progress in biomedicine. In particular, microfluidics with the advantages of high throughput, small sample volume, and the ability to combine with other technologies has a wide range of applications in single-cell analysis. Here, we present an overview of the recent advances in single-cell patterning technology, with a special focus on current physical and physicochemical methods including stencil patterning, trap- and droplet-based microfluidics, and chemical modification on surfaces via photolithography, microcontact printing, and scanning probe lithography. Meanwhile, the methods applied to biological studies and the development trends of single-cell patterning technology in biological applications are also described.en_US
dc.language.isoenen_US
dc.publisherAIP Publishingen_US
dc.relation.urlhttps://aip.scitation.org/doi/10.1063/1.5123518en_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.subjectsingle-cell patterning technologyen_US
dc.titleSingle-cell patterning technology for biological applicationsen_US
dc.typeArticleen_US
dc.contributor.departmentChangchun University of Science and Technologyen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journalBiomicrofluidicsen_US
dc.date.updated2020-06-29T09:16:18Z
dc.description.noteover 3m from publication


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