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dc.contributor.authorYang, Xue
dc.contributor.authorMa, Ke
dc.contributor.authorYang, Libo
dc.contributor.authorChen, Yujuan
dc.contributor.authorQu, Yingmin
dc.contributor.authorWang, Ying
dc.contributor.authorWang, Xinyue
dc.contributor.authorYang, Fan
dc.contributor.authorSun, Qi
dc.contributor.authorSong, Zhengxun
dc.contributor.authorWang, Zuobin
dc.date.accessioned2020-06-25T09:52:42Z
dc.date.available2019-12-11T00:00:00Z
dc.date.available2020-06-25T09:52:42Z
dc.date.issued2019-12-11
dc.identifier.citationYang X, Ma K, Yang L, Chen Y, Qu Y, Wang Y, Wang X, Yang F, Sun Q, Song Z, Wang Z (2019) 'Influence of magnetic field on morphological structures and physiological characteristics of bEnd.3 cells cultured on polypyrrole substrates', RSC Advances, 9 (70), pp.40887-40894.en_US
dc.identifier.issn2046-2069
dc.identifier.doi10.1039/c9ra07180f
dc.identifier.urihttp://hdl.handle.net/10547/624094
dc.description.abstractThis paper employs a spin-coated method to construct conductive polypyrrole (PPy) substrates which present superior properties for controlling the morphological structures and functions of bEnd.3 cells. The PPy substrates with a homogeneous particle size, uniform distribution and proper roughness show enhanced hydrophilic characteristics and improve cell adhesion to the substrates. The changes in the mechanical properties of cells and the responses to the designed substrates and magnetic field are also explored. Due to the synergistic effect between the magnetic field and the conductive PPy substrate, the cells cultured in such an environment exhibit applanate shapes with more branches and enhanced cell viability. In addition, the cells preferentially extend along the magnetic field direction. The mechanical characteristics of cells change significantly under varying magnetic intensity stimulations (5–16 mT). The satisfying effect on cells' morphology and outgrowth is acquired at the magnetic intensities of 9–10 mT and duration of 20 min, compared with other stimulated groups, while retaining cell viability. Moreover, the cells express higher adhesion up to 5.2 nN. The results suggest that the application of the PPy substrates and magnetic field is a promising candidate for the protection of neurovascular units and treatment of neurological diseases.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.urlhttps://pubs.rsc.org/en/content/articlepdf/2019/ra/c9ra07180fen_US
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectpolypyrroleen_US
dc.subjectmagnetic fielden_US
dc.subjectSubject Categories::F110 Applied Chemistryen_US
dc.titleInfluence of magnetic field on morphological structures and physiological characteristics of bEnd.3 cells cultured on polypyrrole substratesen_US
dc.typeArticleen_US
dc.identifier.eissn2046-2069
dc.contributor.departmentChangchun University of Science and Technologyen_US
dc.contributor.departmentUniversity of Bedfordshireen_US
dc.identifier.journalRSC Advancesen_US
dc.date.updated2020-06-25T09:47:08Z
dc.description.noteopen access


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