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    Anti-degranulation response of herbal formula in RBL-2H3 cells

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    Authors
    Hu, Jing
    Chen, Yujuan
    Zhu, Jiajing
    Gao, Mingyan
    Li, Jiani
    Song, Zhengxun
    Xu, Hongmei
    Wang, Zuobin
    Affiliation
    Changchun University of Science and Technology
    University of Warwick
    University of Bedfordshire
    Issue Date
    2019-12-28
    Subjects
    anti-degranulation response
    
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    Abstract
    Allergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.
    Citation
    Hu J, Chen Y, Zhu J, Gao M, Li J, Song Z, Xu H, Wang Z (2020) 'Anti-degranulation response of herbal formula in RBL-2H3 cells', Micron, 130 (102819)
    Publisher
    Elsevier
    Journal
    Micron
    URI
    http://hdl.handle.net/10547/624066
    DOI
    10.1016/j.micron.2019.102819
    PubMed ID
    31896517
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S0968432819303774
    Type
    Article
    Language
    en
    ISSN
    0968-4328
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.micron.2019.102819
    Scopus Count
    Collections
    Computing

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