AffiliationChangchun University of Science and Technology
University of Warwick
University of Bedfordshire
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AbstractAllergic diseases not only bring serious economic burden to the patients, but also consume a lot of substantial resources of social medical systems. Thus, the prevention and treatment of allergic diseases are imperative. In this study, the anti-degranulation activity of herbal formula was evaluated using the rat basophil leukemia cells (RBL-2H3) as in vitro model. The morphological and biophysical properties of RBL-2H3 cells before and after treatment with herbal formula were also determined. Notably, the herbal formula exhibits clearly inhibited degranulation by RBL-2H3 cells in a concentration-dependent manner without cytotoxic effect. Therefore, this herbal formula can be used as an alternative and promising therapeutic agent to ameliorate allergic diseases.
CitationHu J, Chen Y, Zhu J, Gao M, Li J, Song Z, Xu H, Wang Z (2020) 'Anti-degranulation response of herbal formula in RBL-2H3 cells', Micron, 130 (102819)