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    Downregulation of hsa_circ_0000285 serves as a prognostic biomarker for bladder cancer and is involved in cisplatin resistance

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    Authors
    Wang, S.
    Chi, B.
    Zhao, D.
    Liu, L.
    Yin, X.
    Wang, F.
    Bi, S.
    Gui, S.
    Zhou, Shaobo
    Qin, W.
    Wu, D.
    Show allShow less
    Affiliation
    Jiamusi University
    University of Bedfordshire
    Issue Date
    2019-03-19
    Subjects
    resistance
    CircRNA
    chemo-sensitivity
    Bladder cancer
    CircHIPK3
    
    Metadata
    Show full item record
    Abstract
    Bladder cancer remains a very challenging disease to treat with the high rates of recurrence and progression associated with current therapies. Although the association between bladder cancer pathology and circRNAs remains undetermined, circRNAs signatures may be useful as prognostic and predictive factors and clinical tools for assessing disease state, treatment response and outcome. This study investigates if these circRNAs can be used as biomarkers for bladder cancer diagnosis and predicting treatment response. Herein, qPCR measured the expression of hsa_circRNA_100783, hsa_circ_0000285 and hsa_circRNA_100782 in bladder cancer tissues. It was established that sa_circ_0000285, but not hsa_circRNA_100782 and hsa_circRNA_10078, are significantly reduced in bladder cancer tissues and serum compared to adjacent tissues and healthy controls. Moreover, hsa_circ_0000285 expression was lower in cisplatin-resistant bladder cancer patients than in those who were cisplatin-sensitive. Here, hsa_circ_0000285 was associated with tumor size (p<0.001), differentiation (p<0.001), lymph node metastasis (p=0.038), distant metastasis (p=0.004) and TNM stage (p=0.013). Further analysis showed that hsa_circ_0000285 would be an independent prognostic factor for bladder cancer patient outcome. In conclusion, our study indicates hsa_circ_0000285 may be a novel biomarker for bladder cancer because of its involvement in bladder cancer chemo-sensitivity.
    Citation
    Wang S, Chi B, Zhao D, Liu L, Yin X, Wang F, Bi S, Gui S, Zhou S, Qin W, Wu D (2019) 'Downregulation of hsa_circ_0000285 serves as a prognostic biomarker for bladder cancer and is involved in cisplatin resistance', Neoplasma -Bratislava-, 66 (2), pp.197-202.
    Publisher
    AEPress
    Journal
    Neoplasma -Bratislava-
    URI
    http://hdl.handle.net/10547/623779
    DOI
    10.4149/neo_2018_180318N185
    PubMed ID
    30509102
    Additional Links
    http://www.elis.sk/index.php?page=shop.product_details&flypage=flypage.tpl∏uct_id=5954&category_id=147&option=com_virtuemart&vmcchk=1&Itemid=1
    Type
    Article
    Language
    en
    ISSN
    0028-2685
    ae974a485f413a2113503eed53cd6c53
    10.4149/neo_2018_180318N185
    Scopus Count
    Collections
    Biomedical and biological science

    entitlement

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