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dc.contributor.authorKeogh, Sophieen
dc.contributor.authorBridle, Christopheren
dc.contributor.authorSiriwardena, Niroshan A.en
dc.contributor.authorNadkarni, Amulyaen
dc.contributor.authorLaparidou, Despinaen
dc.contributor.authorDurrant, Simon J.en
dc.contributor.authorKargas, Nikoen
dc.contributor.authorLaw, Graham A.en
dc.contributor.authorCurtis, Ffionen
dc.date.accessioned2019-11-15T10:33:20Z
dc.date.available2019-11-15T10:33:20Z
dc.date.issued2019-08-22
dc.identifier.citationKeogh S, Bridle C, Siriwardena NA, Nadkarni A, Laparidou D, Durrant SJ, Kargas N, Law GR, Curtis F (2019) 'Effectiveness of non-pharmacological interventions for insomnia in children with Autism Spectrum Disorder: a systematic review and meta-analysis', PLoS ONE, 14 (8), pp.e0221428-.en
dc.identifier.issn1932-6203
dc.identifier.pmid31437211
dc.identifier.doi10.1371/journal.pone.0221428
dc.identifier.urihttp://hdl.handle.net/10547/623591
dc.description.abstractBackground Autism spectrum disorders (ASD) are a set of neurodevelopmental disorders characterised by behavioural, communication and social impairments. The prevalence of sleep disturbances in children with ASD is 40–80%, with significant effects on quality of life for the children and carers. This systematic review aimed to synthesise evidence of the effects of behavioural interventions to improve sleep among children with ASD. Methods Databases (MEDLINE, PsycINFO, CINAHL, ScienceDirect, Autism Data, CENTRAL, ClinicalTrials.gov and Current Controlled Trials) were searched for published, unpublished and ongoing randomised controlled trials evaluating the effect of non-pharmacological interventions for insomnia in children with autism spectrum conditions. Results Three studies met the inclusion criteria, one provided actigraphy data, one Children’s Sleep Habits Questionnaire (CSHQ) data, and one both actigraphy and CSHQ data for use in meta-analyses. There were significant differences between the behavioural intervention and comparison groups (actigraphy data) for total sleep time (24.41 minutes, 95% CI 5.71, 43.11, P = 0.01), sleep latency (-18.31 minutes, 95% CI -30.84, -5.77, P = 0.004) and sleep efficiency (5.59%, 95% CI 0.87, 10.31, P = 0.02). There was also a favourable intervention effect evident for the subjective CSHQ data (-4.71, 95% CI -6.70, -2.73, P<0.00001). Risk of bias was low across several key domains (randomisation, allocation concealment and reporting), with some studies being unclear due to poor reporting. Conclusions There are very few high quality randomised controlled trials in this area. Here we provide initial synthesised quantitative evidence of the effectiveness of behavioural interventions for treating sleep problems in children with ASD.
dc.language.isoenen
dc.publisherPublic Library of Scienceen
dc.relation.urlhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221428en
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectautism spectrumen
dc.subjectinsomniaen
dc.subjectAutism Spectrum Disorder (ASD)en
dc.subjectC810 Applied Psychologyen
dc.titleEffectiveness of non-pharmacological interventions for insomnia in children with Autism Spectrum Disorder: a systematic review and meta-analysisen
dc.typeArticleen
dc.contributor.departmentLincolnshire Partnership Foundation Trusten
dc.contributor.departmentUniversity of Lincolnen
dc.identifier.journalPLoS ONEen
dc.identifier.pmcidPMC6705823
dc.date.updated2019-11-15T10:29:48Z
html.description.abstractBackground Autism spectrum disorders (ASD) are a set of neurodevelopmental disorders characterised by behavioural, communication and social impairments. The prevalence of sleep disturbances in children with ASD is 40–80%, with significant effects on quality of life for the children and carers. This systematic review aimed to synthesise evidence of the effects of behavioural interventions to improve sleep among children with ASD. Methods Databases (MEDLINE, PsycINFO, CINAHL, ScienceDirect, Autism Data, CENTRAL, ClinicalTrials.gov and Current Controlled Trials) were searched for published, unpublished and ongoing randomised controlled trials evaluating the effect of non-pharmacological interventions for insomnia in children with autism spectrum conditions. Results Three studies met the inclusion criteria, one provided actigraphy data, one Children’s Sleep Habits Questionnaire (CSHQ) data, and one both actigraphy and CSHQ data for use in meta-analyses. There were significant differences between the behavioural intervention and comparison groups (actigraphy data) for total sleep time (24.41 minutes, 95% CI 5.71, 43.11, P = 0.01), sleep latency (-18.31 minutes, 95% CI -30.84, -5.77, P = 0.004) and sleep efficiency (5.59%, 95% CI 0.87, 10.31, P = 0.02). There was also a favourable intervention effect evident for the subjective CSHQ data (-4.71, 95% CI -6.70, -2.73, P<0.00001). Risk of bias was low across several key domains (randomisation, allocation concealment and reporting), with some studies being unclear due to poor reporting. Conclusions There are very few high quality randomised controlled trials in this area. Here we provide initial synthesised quantitative evidence of the effectiveness of behavioural interventions for treating sleep problems in children with ASD.


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