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    Response of MG63 osteoblast cells to surface modification of Ti-6Al-4V implant alloy by laser interference lithography

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    Authors
    Liu, Qi
    Li, Wenjun
    Cao, Liang
    Wang, Jiajia
    Qu, Yingmin
    Wang, Xinyue
    Qiu, Rongxian
    Di, Xu
    Wang, Zuobin
    Liang, Bojian
    Affiliation
    Changchun University of Science and Technology
    China-Japan Union Hospital of Jilin University
    Issue Date
    2017-07-14
    Subjects
    Ti-6Al-4V implant alloy
    laser interference lithography
    surface modification
    surface properties
    cell-substrate interaction
    H673 Bioengineering
    
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    Abstract
    The response of human osteoblast-like osteosarcoma cells (MG63) to surface modification of Ti-6Al-4V implant alloy was investigated by Laser Interference Lithography (LIL). In this work, laser interference lithography was employed to fabricate the microstructures of grooves, dots and dimples onto the surfaces of Ti-6Al-4V samples. Two and three beam LIL systems were developed to carry out the experiments. The laser treatment resulted in the increases of the roughness and the contact angle of water on the implant alloy surfaces. The proliferation of osteoblasts was analyzed by MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide) assay for the time periods of 4 hours, 2 days, 3 days, and 6 days. The MTT test results demonstrated that the laser treatment surfaces had a positive impact on the proliferation of osteoblast cells after 24 hours. The alloy surface morphology and the morphological changes of MG63 cells cultured on the laser textured Ti-6Al-4V surface were observed by Scanning Electron Microscope (SEM). The SEM results indicated that the osteoblast cells were aligned on grooved surfaces and they were prolonged with the structures. Enzymatic detachment results showed that the 20 µm grooved structures provided the better cell adhesion to the textured Ti-6Al-4V surfaces.
    Citation
    Liu A, Li W, Cao L, Wang J, Qu Y, Wang X, Qiu R, Di X, Wang Z, Liang B (2017) 'Response of MG63 osteoblast cells to surface modification of Ti-6Al-4V implant alloy by laser interference lithography', Journal of Bionic Engineering, 14 (327), pp.448-458.
    Publisher
    Elsevier
    Journal
    Journal of Bionic Engineering
    URI
    http://hdl.handle.net/10547/623570
    DOI
    10.1016/S1672-6529(16)60410-9
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S1672652916604109
    Type
    Article
    Language
    en
    ISSN
    1672-6529
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1672-6529(16)60410-9
    Scopus Count
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    Computing

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