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    Study of morphological and mechanical features of multinuclear and mononuclear SW480 cells by atomic force microscopy

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    Authors
    Liu, Jinyun
    Qu, Yingmin
    Wang, Guoliang
    Wang, Xinyue
    Zhang, Wenxiao
    Li, Jingmei
    Wang, Zuobin
    Li, Dayou
    Jiang, Jinlan
    Issue Date
    2017-10-09
    Subjects
    atomic force microscopy
    atomic force microscope
    cancer cells
    C130 Cell Biology
    
    Metadata
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    Abstract
    This article studies the morphological and mechanical features of multinuclear and mononuclear SW480 colon cancer cells by atomic force microscopy to understand their drug‐resistance. The SW480 cells were incubated with the fullerenol concentrations of 1 mg/ml and 2 mg/ml. Morphological and mechanical features including the height, length, width, roughness, adhesion force and Young's modulus of three multinuclear cell groups and three mononuclear cell groups were imaged and analyzed. It was observed that the features of multinuclear cancer cells and mononuclear cancer cells were significantly different after the treatment with fullerenol. The experiment results indicated that the mononuclear SW480 cells were more sensitive to fullerenol than the multinuclear SW480 cells, and the multinuclear SW480 cells exhibited a stronger drug‐resistance than the mononuclear SW480 cells. This work provides a guideline for the treatments of multinuclear and mononuclear cancer cells with drugs.
    Citation
    Liu J, Qu Y, Wang G, Wang X, Zhang W, Li J, Wang Z*, Li D, Jiang J (2018) 'Study of morphological and mechanical features of multinuclear and mononuclear SW480 cells by atomic force microscopy', Microscopy Research and Technique, 81 (1), pp.3-12.
    Publisher
    Wiley
    Journal
    Microscopy Research and Technique
    URI
    http://hdl.handle.net/10547/623560
    DOI
    10.1002/jemt.22950
    PubMed ID
    28990709
    Additional Links
    https://onlinelibrary.wiley.com/doi/abs/10.1002/jemt.22950
    Type
    Article
    Language
    en
    ISSN
    1059-910X
    Sponsors
    EU FP7, Grant/Award Number: BioRA No.612641; China‐EU H2020, Grant/Award Number: FabSurfWAR Nos.2016YFE0112100 and 644971; EU H2020, Grant/Award Number: MNR4SCell No.734174; International Science and Technology Cooperation Program of China, Grant/Award Number: 2012DFA11070; Jilin Provincial Science and Technology Program, Grant/Award Number: 20140414009GH, 20140622009JC and 20160623002TC
    ae974a485f413a2113503eed53cd6c53
    10.1002/jemt.22950
    Scopus Count
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    Computing

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