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    AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract

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    Authors
    Qu, Yingmin
    Wang, Zuobin
    Zhao, Feihu
    Liu, Jinyun
    Zhang, Wenxiao
    Li, Jingmei
    Song, Zhengxun
    Xu, Hongmei
    Affiliation
    Changchun University of Science and Technology
    Eindhoven University of Technology
    University of Bedfordshire
    Issue Date
    2017-10-12
    Subjects
    ginseng-extracted compounds
    American ginseng
    atomic force microscope
    atomic force microscopy
    cell apoptosis
    cellular stiffness
    SMMC-7721 cells
    hepatocelluar carcinoma
    C130 Cell Biology
    
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    Abstract
    American ginseng as a common and traditional herbal medicine has been used in cancer treatment for many years. However, the effect of American ginseng on the cancer cell response (i.e. apoptosis) has not been fully understood yet. Previous studies demonstrated that cellular apoptosis was associated with the changes of mechanical and morphological properties. Therefore, in this study, mechanical and morphological characterizations were carried out by both atomic force microscope (AFM) and inverted optical microscope to investigate the apoptosis of hepatocellular carcinoma (SMMC-7721) cells affected by American ginseng root water extract (AGRWE). The results showed that the cells treated with AGRWE exhibited significantly larger surface roughness, height and elastic modulus values than control group. Moreover, those parameters were upregulated under the higher concentration of AGRWE and longer culture time. Consequently, it indicates that the mechanical and morphological properties can be used as the apoptotic characteristics of SMMC-7721 cells. Also, the increased surface roughness and elastic modulus of cells under the AGRWE treatment have shown that the apoptosis of SMMC-7721 cells can be enhanced by AGRWE. This will provide an important implication for hepatocelluar carcinoma treatment and drug development.
    Citation
    Qu Y, Wang Z, Zhao F, Liu J, Zhang W, Li J, Song Z, Xu H (2018) 'AFM-detected apoptosis of hepatocellular carcinoma cells induced by American ginseng root water extract', Micron, 104, pp.1-7.
    Publisher
    Elsevier
    Journal
    Micron
    URI
    http://hdl.handle.net/10547/623559
    DOI
    10.1016/j.micron.2017.10.003
    PubMed ID
    29049926
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S0968432817303256
    Type
    Article
    Language
    en
    ISSN
    0968-4328
    Sponsors
    “111” Project of China (D17017), EU FP7 (BioRA No.612641), China-EU H2020 (FabSurfWAR Nos.2016YFE0112100 and 644971), EU H2020 (MNR4SCell No.734174), and Jilin Provincial Science and Technology Program (Nos.20160520101JH, 20160101318JC and 20160623002TC)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.micron.2017.10.003
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