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    Cardiomyocyte contractile force changes in response to AGRWE detected by AFM

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    Authors
    Qu, Yingmin
    Zhao, Feihu
    Wang, Xinyue
    Liu, Jinyun
    Li, Jingmei
    Song, Zhengxun
    Wang, Zuobin
    Affiliation
    Changchun University of Science and Technology
    Eindhoven University of Technology
    University of Bedfordshire
    Issue Date
    2019-05-01
    Subjects
    cellular biophysics
    biomechanics
    atomic force microscope
    atomic force microscopy
    cardiovascular system
    C130 Cell Biology
    
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    Abstract
    The cardiac contractile force is an important predictor of healthy and cardiovascular diseases. The changes of cardiomyocyte contractile force in response to American ginseng root water extract (AGRWE) detected by atomic force microscope have not been investigated yet. This study examined the effects of AGRWE on single beating cardiomyocytes extracted from a newborn rat. The same cardiomyocytes were incubated with AGRWE at a concentration of 50 μg/ml for about 30 min, and the cardiomyocytes’ contractile force increased from 1.74 ± 1.01 to 3.49 ± 1.53 nN. The mean value of the contractile strain calculated was 3.32 ± 1.55% for the cardiomyocyte before the treatment with AGRWE, while for the cardiomyocyte treated with AGRWE it increased to 4.60 ± 1.35%. The results also showed that the beating rate of the same single beating cardiomyocytes was decreased from 34 ± 11 beats/min (control, n = 10) to 20 ± 9 beats/min. In conclusion, the experimental results have shown clearly that the contractile forces and strain of single beating cardiomyocytes treated with AGRWE are significantly higher than the control group, while the heart rate was decreased. It suggests that ginseng agents are promising candidates in improving cardiac functions for treating heart failure.
    Citation
    Qu Y, Zhao F, Wang X, Liu J, Li J, Song Z, Wang Z. (2019) 'Cardiomyocyte contractile force changes in response to AGRWE detected by AFM', Micro and Nano Letters, 14 (5), pp.511-514.
    Publisher
    The Institution of Engineering and Technology
    Journal
    Micro and Nano Letters
    URI
    http://hdl.handle.net/10547/623558
    DOI
    10.1049/mnl.2018.5458
    Additional Links
    https://digital-library.theiet.org/content/journals/10.1049/mnl.2018.5458
    Type
    Article
    Language
    en
    ISSN
    1750-0443
    EISSN
    1750-0443
    ae974a485f413a2113503eed53cd6c53
    10.1049/mnl.2018.5458
    Scopus Count
    Collections
    Computing

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