Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro
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AbstractHepatocellular carcinoma (HCC) is one of major leading causes of cancer death worldwide. As a traditional medicine, the anti-cancer function of ginseng is being growingly recognized and investigated. However, the effect of ginseng rust rot on human HCC is unknown yet. In this study, the HCC cells were treated with different parts of mountain cultivated ginseng rust rot and compared with human normal liver cells. The morphology, survival rate and β-actin expression of the cells were changed by introducing the ginseng epidermis during the incubation process. Notably, the results reveal that the ginseng epidermis can induce apoptosis by altering the morphologies of cells, indicating the practical implication for the HCC treatment and drug development.
CitationHu J, Jiao J, Wang Y, Gao M, Lu Z, Yang F, Hu C, Song Z, Chen Y, Wang Z (2019) 'Effect of extract from ginseng rust rot on the inhibition of human hepatocellular carcinoma cells in vitro', Micron, 124 (), pp.102710-.
SponsorsNational Key R&D Program of China (No.2017YFE0112100), EU H2020 Program (MNR4SCELL No.734174), Jilin Provincial Science and Technology Program (Nos. 20160623002TC, 20180414002GH, 20180414081GH, 20180520203JH and 20190702002GH), and “111” Project of China (D17017)
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