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dc.contributor.authorJiang, Xiaolinen
dc.contributor.authorMa, Keen
dc.contributor.authorHu, Cuihuaen
dc.contributor.authorGao, Mingyanen
dc.contributor.authorZhang, Jiashuoen
dc.contributor.authorWang, Yingen
dc.contributor.authorChen, Yujuanen
dc.contributor.authorSong, Zhengxunen
dc.contributor.authorWang, Zuobinen
dc.date.accessioned2019-10-31T10:06:29Z
dc.date.available2019-10-31T10:06:29Z
dc.date.issued2019-09-06
dc.identifier.citationJiang X, Ma K, Hu C, Gao M, Zhang J, Wang Y, Chen Y, Song Z, Wang Z. (2019) 'Evaluations of 5-fluorourcil treated lung cancer cells by atomic force microscopy', Analytical Methods, 11 (), pp.4977-4982.en
dc.identifier.issn1759-9660
dc.identifier.doi10.1039/C9AY01485C
dc.identifier.urihttp://hdl.handle.net/10547/623554
dc.description.abstractAtomic force microscopy (AFM) can be used to obtain the physical information of single live cancer cells; however, the physical changes in live cells with time based on AFM remain to be studied, which play a key role in the evaluation of the efficacy and side effects of drugs. Herein, the treatment of the A549 cell line with the anticarcinogen 5-fluorouracil has been discussed based on the AFM analysis of their continuous physical changes, including their surface morphology, height, adhesion and Young's modulus, with time. In comparison, the African green monkey kidney (Vero) cell line was tested as normal cells to determine the side effects of 5-fluorouracil. The results show that the optimal concentration of 5-fluorouracil is about 500 μM, which presents the best anticancer effect and mild side effects.
dc.description.sponsorshipNational Key R&D Program of China (No.2017YFE0112100), EU H2020 Program (MNR4SCell No.734174), Jilin Provincial Science and Technology Program (Nos.20160623002TC , 20180414002GH, 20180414081GH, 20180520203JH and 20190702002GH), “111” Project of China (D17017) and the Youth Science Fund of Changchun University of Science and Technology (XQNJJ-2018-10)en
dc.language.isoenen
dc.publisherThe Royal Society of Chemistryen
dc.relation.urlhttps://pubs.rsc.org/en/content/articlelanding/2019/ay/c9ay01485c/unauth#!divAbstracten
dc.rightsYellow - can archive pre-print (ie pre-refereeing)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectatomic force microscopyen
dc.subjectcancer cellsen
dc.subjectC741 Medical Biochemistryen
dc.titleEvaluations of 5-fluorourcil treated lung cancer cells by atomic force microscopyen
dc.typeArticleen
dc.contributor.departmentChangchun University of Science and Technologyen
dc.contributor.departmentUniversity of Bedfordshireen
dc.identifier.journalAnalytical Methodsen
dc.date.updated2019-10-31T09:58:46Z
html.description.abstractAtomic force microscopy (AFM) can be used to obtain the physical information of single live cancer cells; however, the physical changes in live cells with time based on AFM remain to be studied, which play a key role in the evaluation of the efficacy and side effects of drugs. Herein, the treatment of the A549 cell line with the anticarcinogen 5-fluorouracil has been discussed based on the AFM analysis of their continuous physical changes, including their surface morphology, height, adhesion and Young's modulus, with time. In comparison, the African green monkey kidney (Vero) cell line was tested as normal cells to determine the side effects of 5-fluorouracil. The results show that the optimal concentration of 5-fluorouracil is about 500 μM, which presents the best anticancer effect and mild side effects.


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