Evaluations of 5-fluorourcil treated lung cancer cells by atomic force microscopy
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AbstractAtomic force microscopy (AFM) can be used to obtain the physical information of single live cancer cells; however, the physical changes in live cells with time based on AFM remain to be studied, which play a key role in the evaluation of the efficacy and side effects of drugs. Herein, the treatment of the A549 cell line with the anticarcinogen 5-fluorouracil has been discussed based on the AFM analysis of their continuous physical changes, including their surface morphology, height, adhesion and Young's modulus, with time. In comparison, the African green monkey kidney (Vero) cell line was tested as normal cells to determine the side effects of 5-fluorouracil. The results show that the optimal concentration of 5-fluorouracil is about 500 μM, which presents the best anticancer effect and mild side effects.
CitationJiang X, Ma K, Hu C, Gao M, Zhang J, Wang Y, Chen Y, Song Z, Wang Z. (2019) 'Evaluations of 5-fluorourcil treated lung cancer cells by atomic force microscopy', Analytical Methods, 11 (), pp.4977-4982.
PublisherThe Royal Society of Chemistry
SponsorsNational Key R&D Program of China (No.2017YFE0112100), EU H2020 Program (MNR4SCell No.734174), Jilin Provincial Science and Technology Program (Nos.20160623002TC , 20180414002GH, 20180414081GH, 20180520203JH and 20190702002GH), “111” Project of China (D17017) and the Youth Science Fund of Changchun University of Science and Technology (XQNJJ-2018-10)
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