Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

Thumbnail
Name:
Publisher version
Thumbnail
Name:
PIIS0091674919309480.pdf
Size:
4.223Mb
Format:
PDF
Download
Authors
Yánez, Diana C.
Lau, Ching-In
Chawda, Mira Manilal
Ross, Susan
Furmanski, Anna L.
Crompton, Tessa
Affiliation
University College London
University of Bedfordshire
Universidad San Francisco de Quito
Issue Date
2019-07-24
Subjects
immunology
immune response
hedgehog proteins
C550 Immunology

Metadata
Show full item record
Abstract
Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.
Citation
Yánez DC, Lau CI, Chawda MM, Ross S, Furmanski AL, Crompton T. (2019) 'Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells', Journal of Allergy and Clinical Immunology, 144 (5), pp.1419-1423.
Publisher
Journal of Allergy and Clinical Immunology
Journal
Journal of Allergy and Clinical Immunology
URI
http://hdl.handle.net/10547/623391
DOI
10.1016/j.jaci.2019.07.011
PubMed ID
31351102
PubMed Central ID
PMC6843897
Additional Links
https://www.jacionline.org/article/S0091-6749(19)30948-0/abstract
https://www.sciencedirect.com/science/article/pii/S0091674919309480
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843897/
Type
Article
Language
en
ISSN
0091-6749
Sponsors
MRC, Wellcome, Asthma UK, SENESCYT, GOS NIHR BRC, Pfizer
Collections

The following license files are associated with this item:

  • Creative Commons
Green - can archive pre-print and post-print or publisher's version/PDF
Except where otherwise noted, this item's license is described as Green - can archive pre-print and post-print or publisher's version/PDF