Sitting time and risk of cardiovascular disease and diabetes: a systematic review and meta-analysis
AffiliationUniversity of Bedfordshire
C600 Sports Science
MetadataShow full item record
AbstractContext: Whether physical activity attenuates the association of total daily sitting time with cardiovascular disease (CVD) and diabetes incidence is unclear. This systematic review and meta-analysis examined the association of total daily sitting time with CVD and diabetes with and without adjustment for physical activity. Evidence Acquisition: PubMed, Web of Science, BASE, MEDLINE, Academic Search Elite and ScienceDirect were searched for prospective studies published between 1st January 1989 and 15th February 2019 examining the association of total daily sitting time with CVD or diabetes outcomes. Data extraction and study quality assessments were conducted by two independent reviewers. Pooled Hazard Ratios (HRs) were calculated using a fixed-effects model. The quality assessment and meta-analytic procedures were completed in 2018. Evidence Synthesis: Nine studies with 448,285 40 participants were included. Higher total daily sitting time was associated with a significantly increased risk of CVD (HR 1.29; 95%CI 1.27-1.30, p=<0.001) and diabetes (HR 1.13; 95%CI 1.04-1.22, p=<0.001) incidence when physical activity was not adjusted for. The increased risk for diabetes was unaffected when adjusting for physical activity (HR 1.11; 95%CI 1.01-1.19, p=<0.001). For CVD, the increased risk was attenuated but remained significant (HR 1.14; 95%CI 1.04-1.23, p=<0.001). Conclusions: Higher levels of total daily sitting time are associated with an increased risk of CVD and diabetes, independent of physical activity. Reductions in total daily sitting may thus be recommended in public health guidelines.
CitationBailey DP, Hewson DJ, Champion RB, Sayegh SM. (2019) 'Sitting time and risk of cardiovascular disease and diabetes: a systematic review and meta-analysis', American Journal of Preventive Medicine, 57 (3), pp.408-416.
The following license files are associated with this item:
- Creative Commons
Except where otherwise noted, this item's license is described as Green - can archive pre-print and post-print or publisher's version/PDF
- Does physical activity attenuate, or even eliminate, the detrimental association of sitting time with mortality? A harmonised meta-analysis of data from more than 1 million men and women.
- Authors: Ekelund U, Steene-Johannessen J, Brown WJ, Fagerland MW, Owen N, Powell KE, Bauman A, Lee IM, Lancet Physical Activity Series 2 Executive Committe., Lancet Sedentary Behaviour Working Group.
- Issue date: 2016 Sep 24
- Sedentary time and its association with risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis.
- Authors: Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS, Alter DA
- Issue date: 2015 Jan 20
- Sedentary behavior and cardiovascular disease in older women: The Objective Physical Activity and Cardiovascular Health (OPACH) Study.
- Authors: Bellettiere J, LaMonte MJ, Evenson KR, Rillamas-Sun E, Kerr J, Lee IM, Di C, Rosenberg DE, Stefanick M, Buchner DM, Hovell MF, LaCroix AZ
- Issue date: 2019 Feb 19
- Changes in Sitting Time and Cardiovascular Mortality in Older Adults.
- Authors: Cabanas-Sánchez V, Guallar-Castillón P, Higueras-Fresnillo S, Rodríguez-Artalejo F, Martínez-Gómez D
- Issue date: 2018 Mar
- Sitting Time, Physical Activity, and Risk of Mortality in Adults.
- Authors: Stamatakis E, Gale J, Bauman A, Ekelund U, Hamer M, Ding D
- Issue date: 2019 Apr 30