Procedural and declarative memory task performance, and the memory consolidation function of sleep, in recent and abstinent ecstasy/MDMA users
Authors
Blagrove, MarkSeddon, Jennifer L.
George, Sophie
Parrott, Andrew C.
Stickgold, Robert
Walker, Matthew P.
Jones, Katy A.
Morgan, Michael J.
Issue Date
2010-07-08
Metadata
Show full item recordAbstract
Ecstasy/MDMA use has been associated with various memory deficits. This study assessed declarative and procedural memory in ecstasy/MDMA users. Participants were tested in two sessions, 24 h apart, so that the memory consolidation function of sleep on both types of memory could also be assessed. Groups were: drug-naive controls (n = 24); recent ecstasy/MDMA users, who had taken ecstasy/MDMA 2-3 days before the first testing session (n = 25), and abstinent users, who had not taken ecstasy/MDMA for at least 8 days before testing (n = 17). Procedural memory did not differ between groups, but greater lifetime consumption of ecstasy was associated with poorer procedural memory. Recent ecstasy/MDMA users who had taken other drugs (mainly cannabis) 48-24 h before testing exhibited poorer declarative memory than controls, but recent users who had not taken other drugs in this 48-24-h period did not differ from controls. Greater lifetime consumption of ecstasy, and of cocaine, were associated with greater deficits in declarative memory. These results suggest that procedural, as well as declarative, memory deficits are associated with the extent of past ecstasy use. However, ecstasy/MDMA did not affect the memory consolidation function of sleep for either the declarative or the procedural memory task.Citation
Blagrove M, Seddon J, George S, Parrott AC, Stickgold R, Walker MP, Jones KA, Morgan MJ (2011) 'Procedural and declarative memory task performance, and the memory consolidation function of sleep, in recent and abstinent ecstasy/MDMA users', Journal of Psychopharmacology, 25 (4), pp.465-477.Publisher
SAGEJournal
Journal of PsychopharmacologyPubMed ID
20615932PubMed Central ID
PMC3604193Additional Links
https://journals.sagepub.com/doi/full/10.1177/0269881110372545https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604193/
Type
ArticleLanguage
enISSN
0269-8811ae974a485f413a2113503eed53cd6c53
10.1177/0269881110372545
Scopus Count
Collections
Related articles
- MDMA, serotonergic neurotoxicity, and the diverse functional deficits of recreational 'Ecstasy' users.
- Authors: Parrott AC
- Issue date: 2013 Sep
- Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction.
- Authors: Quednow BB, Jessen F, Kuhn KU, Maier W, Daum I, Wagner M
- Issue date: 2006 May
- Neuropsychological function in ecstasy users: a study controlling for polydrug use.
- Authors: Roiser JP, Rogers RD, Sahakian BJ
- Issue date: 2007 Jan
- Ecstasy (MDMA) effects upon mood and cognition: before, during and after a Saturday night dance.
- Authors: Parrott AC, Lasky J
- Issue date: 1998 Oct
- MDMA in humans: factors which affect the neuropsychobiological profiles of recreational ecstasy users, the integrative role of bioenergetic stress.
- Authors: Parrott AC
- Issue date: 2006 Mar